1662. Clinical Usefulness of Brain functional MRI for Diagnosing HIV-associated Neurocognitive Disorder in HIV-infected patients
Session: Poster Abstract Session: HIV: Neurological Complications and HAND
Saturday, October 10, 2015
Room: Poster Hall
Background: HIV-associated neurocognitive disorder (HAND) can occur in patients without prior acquired AIDS defining illness and can be quite debilitating. The diagnosis of HAND can also be challenging by requiring several detailed neuropsychological (NP) examinations. This study evaluated the use of functional MRI to scan of the brain in patients with or without HAND as a way to diagnose HAND.

Methods: We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 12 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied.

Results: Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function. One patient was ruled out because of aggravated liver cirrhosis. Among the 12 patients who had previously demonstrated normal neurocognitive function, 2 patients showed neurocognitive impairment. The HAND group showed significant decrease of resting status functional connectivity between bilateral precuneus cortex (PCC) and prefrontal cortex (PFC) compared with the nonHAND group (p<0.001).

Conclusion: In this cross-sectional study, we found a significant difference in fMRI patterns between HAND and nonHAND groups. These patterns on functional brain MRI may be useful to screen for HAND, which should be characterized in a longitudinal study.

Hea Won Ann, MD1,2, Yong Duk Jeon, MD2, Jin Young Ahn, MD2, Nam Su Ku, MD2, June Myung Kim, MD, PhD2, Na-Young Shin, MD3, Davey M. Smith, MD, PhD4, Jun Yong Choi, MD, PhD2, Suhnyoung Jun, BD5, Mi-Young Ahn, MD2, Sanghoon Han, phD6 and In Young Jung, MD2, (1)AIDS Research Institute, Seoul, South Korea, (2)Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, (3)Department of Radiology, Ewha Womans University School of Medicine, seoul, South Korea, (4)Department of Medicine, University of California San Diego, san diego, CA, (5)Integrated Neurocognitive Functional Imaging Center, Yonsei University, seoul, South Korea, (6)Department of Psychology, Yonsei University, seoul, South Korea

Disclosures:

H. W. Ann, None

Y. D. Jeon, None

J. Y. Ahn, None

N. S. Ku, None

J. M. Kim, None

N. Y. Shin, None

D. M. Smith, None

J. Y. Choi, None

S. Jun, None

M. Y. Ahn, None

S. Han, None

I. Y. Jung, None

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