477. Asymptomatic Children Might Transmit Human Parechovirus Type 3 to Neonates and Young Infants
Session: Poster Abstract Session: Pediatric Viral Infections
Thursday, October 8, 2015
Room: Poster Hall
  • poster upload—p IDSA 2015 poster HPeV asymptomatic children.pdf (171.9 kB)
  • Background: Human parechovirus type 3 (HPeV3) epidemics occur worldwide and can lead to severe disease in neonates and young infants. Little is known about the source of HPeV3 infection.

    Methods: To investigate the source of HPeV3 infection and the role of asymptomatic children in the families of infected children, during a 2014 HPeV3 epidemic in Niigata, Japan, we analyzed (1) clinical information on sick contacts for 43 neonates and young infants with HPeV3-related disease diagnosed by PCR analysis of serum and/or cerebrospinal fluid and (2) stool samples from symptomatic and asymptomatic siblings/cousins of index patients.

    Results: Sick contact with family members was confirmed for 51% (n = 22) of patients. Among the 30 symptomatic family members, 67% (n = 20) were siblings, 20% (n = 6) were mothers, and 13% (n = 4) were other relatives. Cough and/or rhinorrhea were more frequent in children (14/22, 64%) than in adults (2/8, 25%) (P = 0.101). Fever was more frequent in adults (6/8, 75%) than in children (9/22, 41%) (P = 0.215). Stool samples from symptomatic and asymptomatic siblings/cousins of 4 HPeV3-infected patients yielded positive results for HPeVs on PCR analysis. Furthermore, VP1 nucleotide sequences of family members were 100% identical to those of the respective index cases; thus, asymptomatic family members were the probable source of infection.

    Conclusion: Identification of genetically identical virus from HPeV3-infected patients and asymptomatic children in their families suggests that the latter are a source of infection in neonates and young infants with HPeV3-related diseases.

    Yuta Aizawa, MD1, Takayuki Yamanaka, MD2, Kanako Watanabe, PhD3, Tomohiro Oishi, MD, PhD1 and Akihiko Saitoh, MD, PhD1,4, (1)Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, (2)Niigata Medicalcare Cooperative Kido Hospital, Niigata, Japan, (3)Niigata University Graduate School of Health Sciences, Niigata, Japan, (4)University of California, San Diego, La Jolla, CA


    Y. Aizawa, None

    T. Yamanaka, None

    K. Watanabe, None

    T. Oishi, None

    A. Saitoh, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.