1164. Global Estimates of Meningococcal Meningitis Case Fatality Ratios by Region for Children and Adults
Session: Poster Abstract Session: Public Health
Friday, October 9, 2015
Room: Poster Hall
Posters
  • Greenbaum_Meningococcal Meningitis CFR_Oct_2015.pdf (367.9 kB)
  • Background:  No global disease burden estimates exist for Neisseria meningitidis meningitis. We developed a model to estimate meningococcal deaths, using incidence rates and case fatality ratios (CFR).  We evaluated CFRs by country, region, age and epidemiologic setting.

    Methods: We abstracted meningococcal meningitis cases, deaths, and CFRs from published and unpublished literature from 1980-2014.

    Results: Of 170 studies (79 countries) with CFRs, we excluded 34 studies (13 countries) with n≤20 cases.  Results are in table below.

     

    Africa

    Asia

    Europe

    Latin Amer

    Oceania

    North Amer

     

    Meningitis Belt

    Non-Men Belt

     

    Endemic

    Epidemic

    Endemic

    Epidemic

    Studies, n

    35

    26

    9

    8

    28

    26

    20

    15

    3

    Countries, n

    17

    10

    6

    6

    11

    19

    7

    2

    1

    CFR % (range)

    All ages

    3-20

    2-25

    10-22

    4-22

    7-25

    0-12

    3-38

    2-16

    9

    <5 yrs

    7-29

    4-16

    4-23

    -

    3-17

    1-11

    7-44

    -

    5

    5-19 yrs

    8-9

    1-22

    9

    -

    4-16

    2-3

    7-19

    -

    10

    20+ yrs

    13-19

    10-15

    33

    -

    -

    3-21

    10-13

    -

    16

     

    Conclusion: All regions reported meningococcal meningitis CFRs which ranged from 0-44%CFRs were highest in Africa, Asia and Latin America where incidence is likely also highest. Meningococcal vaccination is an important policy consideration to reduce meningococcal mortality. 

    Adena Greenbaum, MD, MPH1, Cristina Garcia, MHS2, Brian Wahl, MPH2, Maria Knoll, PhD2 and Katherine L. O'brien, MD, MPH2, (1)Johns Hopkins Hospital, Baltimore, MD, (2)Johns Hopkins School of Public Health, Baltimore, MD

    Disclosures:

    A. Greenbaum, None

    C. Garcia, None

    B. Wahl, None

    M. Knoll, None

    K. L. O'brien, None

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