Methods: In total 200 strains of Staphylococcus aureus (100–MRSA, 100–MSSA) isolated from patients with community-acquired and nosocomial infections in different regions of Russia were tested. MICs of antimicrobials were determined using broth microdilution method according to ISO and EUCAST methodology.
Results: The results of susceptibility testing are summarized in the Table.
|Antimicrobial||MIC50/MIC90/MIC ranges (mg/l) for MRSA||MIC50/MIC90/MIC ranges (mg/l) for MSSA|
Conclusion: Nemonoxacin was substantially more active in vitro than ciprofloxacin and levofloxacin against tested S.aureus strains. At the same time, activity of Nemonoxacin against MRSA was notably lower than against MSSA – MIC50/90 0.5/05 mg/l versus 0.03/0.06 mg/l, respectively. The activity of Nemonoxacin against ciprofloxacin-resistant S.aureus strains was also substantially lower than against ciprofloxacin-susceptible strains - MIC50/90 0.5/05 mg/l and 0.03/0.06 mg/l, respectively. Overall nemonoxacin was one of the most in-vitro active antimicrobials tested.
M. Sukhorukova, None
M. Edelstein, None
M. Samsonov, None