545. Clinical & Molecular Epidemiology of Respiratory Viruses in a Tertiary Care Center During the 2009-2014 Consecutive Winter Seasons
Session: Poster Abstract Session: Respiratory Viruses
Thursday, October 8, 2015
Room: Poster Hall
  • IDSA2015ANTALIS.pdf (2.8 MB)
  • Background:

    The clinical & molecular epidemiology of respiratory tract infections during 6 consecutive influenza influenza seasons in a tertiary care hospital ER, in Athens, Greece. 


    Consecutive patients with symptoms of respiratory tract infection visiting the ER of a tertiary care hospital were evaluated during the 2009-15 consecutive winter seasons. Clinical samples were collected into ThinPrep CytoLyt® solution. CLART® PneumoVir kit, (Genomica, Spain) was used for viral detection of all known respiratory viruses. Clinical & epidemiological data were collected through a structured questionnaire.


    642 consecutive patients (mean age 42.4 yrs, IQR 25-61yrs, 50.4% male) have been evaluated. Overall in 54.3% a respiratory virus has been identified. Any viral or mixed viral infections were more common in children (both p<0.001). The most prevalent respiratory viruses identified during the time of the study were: Influenza:32.2 % (95%CI: 28.5%-36.2%) &  Respiratory Syncytial Virus (RSV): 23.2 % (95%CI: 19.9%-26.9%). Other viruses identified in order of frequency included: Parainfluenza viruses (PIV): 3.1% (95%CI 1.9 %-4.9%); Rhinovirus: 2.5 % (95% CI 1.5-4.3%); human Metapneumovirus (hMPV): 1.9 % (95%CI 1-3.4%); adenovirus: 1% (95%CI 0.4-2.3%); bocavirus: 0.3% (95%CI 0.05-1.3%) & coronavirus: 0.2% (95% CI 0.01-1%) . Mixed infections were identified in 10.3 % (95%CI 8-13.1%) of pts (most frequently influenza & RSV). Rates of influenza & rhinovirus were comparable between children & adults whereas RSV (p < 0.001) & hMPV (p=0.007) were more commonly seen in children. 


    High rates of RSV were noted during all winter seasons co-circulating with influenza. High rates of mixed infections especially with RSV & influenza were observed. Both single and mixed viral infections were more common in children.

    Emmanouil Antalis, MSc1, Christine Kottaridi, MSc, PhD2, Athanasios Kossyvakis, PhD3, Maria Magkana, MSc4, Aris Spathis, PhD2, Zacharoula Oikonomopoulou, MD1, Aikaterini Katsouli, Medical student1, Christina Perlepe, MD1, Garyfallia Poulakou, MD, PhD1, Andreas Mentis, MD, PhD3, Vassiliki Papaevangelou, MD, PhD5, Vassileios Tsagris, MD5, Christos Kroupis, MSc, PhD6, Petros Karakitsos, MD, PhD2 and Sotirios Tsiodras, MD, PhD, Assoc Professor1, (1)4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece, (2)Department of Cytopathology, University of Athens Medical School, Athens, Greece, (3)National Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece, (4)Department of Cytopathology, University of Athens, Medical School, Athens, Greece, (5)Department of Pediatrics, University of Athens Medical School, Athens, Greece, (6)Department of Clinical Biochemistry, University of Athens Medical School, Athens, Greece


    E. Antalis, None

    C. Kottaridi, None

    A. Kossyvakis, None

    M. Magkana, None

    A. Spathis, None

    Z. Oikonomopoulou, None

    A. Katsouli, None

    C. Perlepe, None

    G. Poulakou, None

    A. Mentis, None

    V. Papaevangelou, None

    V. Tsagris, None

    C. Kroupis, None

    P. Karakitsos, None

    S. Tsiodras, None

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