Methods: This is a retrospective, electronic chart review of hospitalized, non-critically-ill adults, who received the combination of vancomycin with either traditional-infusion PT or extended-infusion PT for at least 72 hours. The primary endpoint of this study is the incidence of AKI between treatment groups. Secondary endpoints include the incidence of AKI in selected subgroups, in-hospital mortality, 30-day mortality, and length of stay.
Results: Fifty-seven and 62 patients were included in the traditional- and extended-infusion groups, respectively. Acute kidney injury was observed in 15.7% (9/57) of patients in the traditional-infusion group and 29% (18/62) of patients in the extended-infusion group (p=0.12). There was a significant increase in AKI with extended-infusion PT dosing for patients with Charlson Severity Index scores ≥ 5 (p=0.023) and patients with diabetes mellitus (p=0.008). Mortality and length of stay were similar between both groups.
Conclusion: This study did not find a difference in the incidence of AKI with different PT dosing strategies; however, in patients with multiple co-morbidities, including diabetes mellitus, an increased incidence of AKI was observed in the extended-infusion PT group.
L. Young, None