1750. Population-based study of incidence and antimicrobial resistance patterns of extraintestinal Escherichia coli infections in children in Olmsted County, Minnesota, 2012
Session: Poster Abstract Session: Pediatric Bacterial Infections
Saturday, October 10, 2015
Room: Poster Hall
Posters
  • IDSA 2015_Uzodi_RB (2).pdf (351.3 kB)
  • Background: The population level incidence of extraintestinal E. coli infections in children, including those caused by multidrug-resistant (MDR) strains, is not known. We determined the incidence and antimicrobial resistance profiles of extraintestinal E. coli infections in children in Olmsted County, Minnesota in 2012.

    Methods: We conducted a population-based study using the Rochester Epidemiology Project (REP), a research infrastructure linking medical records of Olmsted County residents. Incident cases were children 0-18 years of age, residents of Olmsted County, with E. coli cultured from any extraintestinal source from 01/01/2012 through 12/31/2012. Polymicrobial cultures were included from all specimen types except urine. Incident urinary tract infection (UTI) cases were defined as subjects with monomicrobial E. coli cultured from urine at >105 CFU/ml, and fever, dysuria, or pyuria. MDR isolates were resistant to 3 or more antimicrobial drugs/drug classes

    Results: There were 217 distinct children with E. coli infection (median age 7 years, 92% female, 97% with UTI). Incidence per 100,000 person-years was 535 overall, 519 for E. coli UTI and 6 for E. coli bloodstream infection (BSI). Incidence differed significantly by age group (p<0.001) and gender (p<0.001); and was highest among female infants and adolescents. Twenty-two (10%) children had MDR isolates and 76 (35%) had isolates resistant to 1-2 drug classes. MDR E. coli infection incidence was 53 per 100,000 person-years. Antimicrobial resistance was higher for ampicillin, ampicillin-sulbactam, trimethoprim-sulfamethoxazole and 1st generation cephalosporins than for other drug classes.

    Conclusion: In our region of the US Midwest, the incidence of E. coli UTI and BSI in children in 2012 is higher than observed in previous years. E. coli isolates demonstrate increased resistance to 1st generation cephalosporins, commonly used first-line agents for treatment of E. coli UTI.  Providers should be aware of the changing epidemiology of E. coli infections in children.

    Adaora Uzodi, MD, MPH1, Christine Lohse, MS2 and Ritu Banerjee, MD, PhD1, (1)Division of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, (2)Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN

    Disclosures:

    A. Uzodi, None

    C. Lohse, None

    R. Banerjee, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.