584. Xpert MTB / RIF vs. Sputum Smear for  TB Screening in an Area of High Prevalence of Pulmonary TB/MDR-TB  in Colombia
Session: Poster Abstract Session: TB: Mycobacteria Diagnostic Testing
Thursday, October 8, 2015
Room: Poster Hall
  • 584.png (340.3 kB)
  • Background: WHO’s current policies and guidance recommend that Xpert MTB/RIF be used as an initial diagnostic test in individuals suspected of having MDR-TB or HIV-associated TB. Recently it has been suggested for TB screening in general population. The aim of this study was to compare screening with XpertMTB / RIF vs. sputum smear microscopy in Buenaventura, Colombia (area of high prevalence of pulmonary TB).

    Methods: Cross-sectional study in adults with respiratory symptoms (for more than 2 weeks) in the community.

    Results: 298 patients were included. The sputum smear was positive in 5.3 % vs.  7.4% with Xpert. The sensitivity of smear and Xpert vs. culture was 53% vs 75%,  specificity 93% vs 95%, positive predictive value 37.5% vs 36.4 % and negative predictive value. 98.5% vs 97%, respectively.

    Conclusion: In our study XpertMTB / RIF showed better performance than sputum smear in suspected TB cases in the community.  Replacing smear microscopy with Xpert MTB/RIF could increase confirmation of pulmonary TB with an additional benefit of rifampicin resistance detection.

    Fernando Rosso, MD, MSC1,2, Robinson Pacheco, MSC2 and Jorge Gonzalez, MD, MSc3, (1)Infectious Diseases, Fundacion Valle del Lili, Cali, Colombia, (2)Clinical Research Center, Fundacion Valle del Lili, Cali, Colombia, (3)Medicos sin fronteras (Francia), Buenaventura, Colombia


    F. Rosso, None

    R. Pacheco, None

    J. Gonzalez, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.