1156. Pandemic influenza preparedness: preparation of a research platform to ensure a timely response
Session: Poster Abstract Session: Public Health
Friday, October 9, 2015
Room: Poster Hall
Posters
  • S Ball Pandemic Preparedness Version 2 REV 6.pdf (145.7 kB)
  • Background:

    Pandemic influenza can result in a rapidly escalating epidemic in populations with little or no pre-existing immunity. Information from public health research can inform strategies to control and prevent pandemic influenza infection.  During the 2009 pandemic, some public health research was not initiated in a timely fashion due to delays related to protocol development, site selection, institutional review board approval, and lack of flexible funding mechanisms. To prepare for the next pandemic, CDC developed a new research platform to enable rapid initiation of special epidemiological studies in the event of a future influenza pandemic.

    Methods:

    The Pandemic Preparedness Meta-Project was created in September 2013 to provide a platform to address four main objectives: to estimate incidence and antiviral and vaccine effectiveness during the pandemic and to describe epidemiologic characteristics of pandemic influenza infection.  Sites were selected to optimize data collection for outpatients and inpatients with acute respiratory illness and to establish longitudinal cohorts of pregnant women, healthcare personnel and first responders, and households.  

    Results:

    By September, 2015, all preparatory work will be completed.  Protocols and data collection instruments were finalized; all had shared data elements.  A common data management system was developed.  14 sites were selected for various components and IRB submissions initiated. Central laboratories were identified.  Pre-pandemic training of staff will be done to ensure a standardized approach across study sites.  Sites and protocols will be maintained in a readiness state in future years. In addition, sub-studies were developed to assess immune responses to illness and vaccine, monitor for antiviral resistance, evaluate viral shedding and collect specimens for genomic studies.

    Conclusion:

    A comprehensive, flexible, and nimble research study platform is being established for deployment when pandemic influenza emerges in the U.S. The Pandemic Preparedness Meta-Project will generate data to inform a timely and appropriate public health response.

    Sarah Ball, MPH, ScD1, Mark G. Thompson, PhD2, Alicia M. Fry, MD, MPH2, Sam Bozeman, MPH1, Angela P. Campbell, MD, MPH, FPIDS3, Fatimah S. Dawood, MD2, Seema Jain, MD, MPH2, Jill Ferdinands, PhD, MSc3, Sandra Dos Santos Chaves, MD2, Matthew Biggerstaff, MPH2, Swathi Thaker, PhD2, Sarah Spencer, PhD2 and Patricia Shifflett, RN, MS4, (1)Abt Associates, Cambridge, MA, (2)Centers for Disease Control and Prevention, Atlanta, GA, (3)Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, (4)Abt Associates, Atlanta, GA

    Disclosures:

    S. Ball, None

    M. G. Thompson, None

    A. M. Fry, None

    S. Bozeman, None

    A. P. Campbell, None

    F. S. Dawood, None

    S. Jain, None

    J. Ferdinands, None

    S. Dos Santos Chaves, None

    M. Biggerstaff, None

    S. Thaker, None

    S. Spencer, None

    P. Shifflett, None

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