533. Bocavirus in patients with severe acute respiratory infections, is it a real pathogen?
Session: Poster Abstract Session: Respiratory Infections: Viral (non Influenza)
Thursday, October 8, 2015
Room: Poster Hall
Posters
  • Bocavirus IDweek 2015 533.pdf (3.0 MB)
  • Background: There is litlle information about the role of Bocavirus as aetiology of respiratory infections. The objective of this study was to describe the clinical and epidemiological charachteristics of patients with severe acute respiratory infections (SARI) with Bocavirus infection and compare them with patients with identification of other viruses.

    Methods: A cross-sectional study was conducted in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients submitted to the surveillance system. Patients with identification of Bocavirus were compared to patients with other viruses and further descriptions of clinical features and relevant clinical outcomes, such as mortality, need for critical care, use of mechanical ventilation and hospital stay, were obtained.

    Results: Of 91 patients with SARI, 26 were identified with Bocavirus (28.5%) and 37 with other viruses (Influenza 48,6%, Adenovirus 40,5%, Parainfluenza 13,5%, and others). Patients with Bocavirus had an average age of 52 years old, 23% had COPD, and 11.5% had heart failure. 57% of the patients were hypoxemic at admission,   46% had pneumonia, 42% required mechanical ventilation, 53% were admitted in ICU and 19% died. There were no  differences found between patients with Bocavirus in comparison with patients with other viruses, except for the frequency of mixed viral infections (57,6% vs. 29,7%,  p=0.026).

    Conclusion: Bocavirus appears to be a frequent cause of hospitalization in patients with respiratory infection. There is a high frequency of pneumonia, need of ICU and mortality, but coninfection with other viruses wer more frequently found, so the role of Bocavirus infection is still debatable.

    Jorge Cortes, MD1, Liliana Diaz, MD2, Sandra Gomez, MSc2, Alejandra Guarnizo, M.D.3, Tatiana Olarte, BSc3, María Ulloa, MD4, Yuly Remolina, M.D.3, Hernan Vargas, PHD2, Alfredo Saavedra, MD3 and Edgar Sanchez, M.D.3, (1)Medicine, Universidad Nacional de Colombia, Bogota, Colombia, (2)Public Health Laboratory, Secretaría Distrital de Salud, Bogotá, Colombia, (3)Internal Medicine, Universidad Nacional de Colombia, Bogotá, Colombia, (4)Universidad Nacional de Colombia, Bogota, Colombia

    Disclosures:

    J. Cortes, None

    L. Diaz, None

    S. Gomez, None

    A. Guarnizo, None

    T. Olarte, None

    M. Ulloa, None

    Y. Remolina, None

    H. Vargas, None

    A. Saavedra, None

    E. Sanchez, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.