Background: Among diabetic patients, 20% of hospital admissions are due to diabetic foot infections (DFIs). DFI is also the most important cause of lower extremity amputations. Increased level of soluble urokinase-type plasminogen activator receptor (suPAR) is accepted as markers of activation of immune and inflammatory systems. In this study we aimed to investigate whether the level of serum suPAR is correlated with the severity of diabetic foot infection or not and whether it has superiority to conventional infection markers such as white blood cell count (WBC), erythrocyte sedimentation rate (ESH), c-reactive protein (CRP), procalcitonin (PCT) or not.
Methods: Patients those are diagnosed as diabetic foot ulcer and DFI in Izmir Katip Celebi University Ataturk Training Research Hospital, between April 2014 and April 2015 were enrolled in the study. Healthy individuals and diabetic patients without any infection focus were defined as control group. DFI diagnosis and severity of infection were based on Infectious Diseases Society of America (IDSA) guidelines. Participants were classified in 4 groups. Conventional infection markers (WBC, ESH, CRP, PCT) were studied for each participant. ELISA method was used for suPAR detection in peripheral blood.
Results: Totally 159 patients; 81 (%50.9) male and 78 (%49.05) female, were enrolled into study. All of infection markers including suPAR were significantly higher in Group 4 compared to others (p=0.000)(Table 1). A significant correlation was also found in severity of infection (Table 2). suPAR and ESH levels were significantly higher in patients with osteomyelitis (p=0.041; p=0.001).
Conclusion: Results of our study suggest that suPAR is an alternative infection marker in DFIs. High levels of suPAR have correlation with severity of infection. And it can be used as an alternative marker to ESH in osteomyelitis.
A. Nemli, None
H. Erbak, None
C. Aslan, None
I. Vardar, None
R. Sutcu, None
See more of: Poster Abstract Session