1730. Bloodstream Infection, a Major Concern in Bangladesh; a Retrospective Analysis
Session: Poster Abstract Session: Infection Prevention: Infection Prevention in Resource Limited Environments
Saturday, October 10, 2015
Room: Poster Hall

Background:

Bloodstream infection by bacterial pathogens is a major cause of morbidity and mortality in developing countries. In poor countries, most of the patients are treated empirically based on their clinical symptoms. Therefore, up to date etiological data of major bloodstream infection causing pathogens can improve the patient's prognosis to final outcome. The aim of this study was to characterize the major bloodstream infection causing pathogens along with their antibiotic susceptibility pattern from Dhaka, Bangladesh.

Methods:

From January 2005 to December 2014, a total of 103679 blood samples were collected from both hospitalized and domiciliary patients. Blood pathogens were identified and characterized by following standard microbiological procedures. Antibiogram was performed using disc diffusion method following CLSI guidelines.

Results:

On average 13.60% of the samples appeared positive and of which Gram negative (72.12%) bacteria were predominant. Children less than 5 years of age (45%) were the most susceptible group. Isolated pathogen showed increased level of resistance to most of the antibiotics used . Salmonella Typhi was the most frequently isolated organism (36.85%), with a high MDR (40.24%) (resistant against ≥ 3 classes of antibiotics). However, reduced trend of resistance was found against ampicillin and cotrimoxazole (P < 0.001). Pseudomonas species was also isolated at a higher percentage (12.51%) and almost 70% was found in adults. Streptococcus pneumoniae was highly prevalent among children (OR: 3.827, 2.922-5.012, P < 0.001), with relatively low (11.96%) level of MDR strains. Overall, Gram positive bacteria were more resistant to the commonly used antibiotics than Gram negative bacteria, however MDR level was high in both groups .

 

 

 

 

 

Conclusion:        

In this study, we identified the major bloodstream infection causing pathogens from Dhaka, Bangladesh.  A major change was observed in antibiotic susceptibility pattern with high MDR level among the pathogens. Given the scarcity of etiological data from developing countries, our study will help physicians to provide better care to patients.

                                           

 

 

 

 

Dilruba Ahmed, PhD1, Md. Ausrafuggaman Nahid, MS2 and Anowar Hossain, MD2, (1)Clnical Microbiology Laboratory, International Centre for Diarrheal Diseases Research, Bangladesh, Dhaka, Bangladesh, (2)International Centre for Diarrheal Diseases Research, Bangladesh, Dhaka, Bangladesh

Disclosures:

D. Ahmed, None

M. A. Nahid, None

A. Hossain, None

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