1897. Impact Of Trivalent Influenza Vaccination Of Pregnant Women On Recurrent Respiratory Infections And Weight Gain In The First 6 Months Of Life
Session: Poster Abstract Session: Vaccines: Influenza
Saturday, October 10, 2015
Room: Poster Hall
Background: Preventing stillbirth, low birth weight, small size for gestational age and prematurity are important potential effects of antenatal maternal immunization with influenza vaccines for which there are conflicting data from predominantly observational studies.

Methods: We conducted two double-blind, randomized, placebo-controlled trials of trivalent inactivated influenza vaccine (IIV3) in South Africa during 2011 in pregnant women infected with HIV and during 2011 and 2012 in pregnant women who were not infected. Here we evaluated the effect of IIV3 during pregnancy against recurrent infections (2 or more episodes in 6 months) and subsequent weight gain.

Results: 2116 HIV-uninfected and 194 HIV infected pregnant women, received either IIV3 or placebo given during pregnancy at an estimated gestation of 20 - 36 weeks. The 2036 infants of HIV uninfected mothers and 185 of HIV infected mothers who had been vaccinated >14 days prior to the outcome were followed to 6 months of age. There was no difference in recurrent influenza like illness and recurrent upper respiratory infections in the infants of HIV uninfected and infected mothers. 2 infants born to HIV uninfected mothers in the placebo group had recurrent lower respiratory infections, and none in any infants of the other groups of IIV 3 or placebo vaccinated mothers. The IIV3 group had significantly greater increases in median weight centiles than the placebo group, between birth and 16 weeks of age (XMv = 12.2, XMp = 5.9; P = 0.038) in the infants of HIV-negative mothers. There were no statistically significant differences in weight gains in the infants of HIV-positive mothers.

Conclusion: There was no evidence of a beneficial effect of antenatal IIV3, on recurrent infections but there was a beneficial effect on weight gains in the first 6 months of life in infants of HIV uninfected immunized mothers.

Eric A. F. Simões, MB; BS, DCH, MD1,2,3, Claire Cutland, MD4, Phyllis Carosone-Link, MSPH5, Andrea Hugo, MD1, Stephanie Jones, MD1, Keith Klugman, MD, PhD, FIDSA1, Marta Nunes, PhD1, Shabir Madhi, MD, PhD6 and MatFlu Team, (1)Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa, (2)Pediatric Infectious Disease, University of Colorado School of Medicine, Aurora, CO, (3)Department of Epidemiology and Center for Global Health, Colorado School of Public Health, Aurora, CO, (4)DST/NRF Vaccine Preventable Diseases, University of the Witwatersrand, South Africa, Johannesburg, South Africa, (5)Childrens Hospital Colorado, Aurora, CO, (6)Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Bertsham, South Africa

Disclosures:

E. A. F. Simões, Bill and Melinda Gates Foundation: Grant Investigator , Research support

C. Cutland, Bill and Melinda Gates Foundation: Grant Investigator , Research support

P. Carosone-Link, Bill and Melinda Gates Foundation: Grant Investigator , Research support

A. Hugo, Bill and Melinda Gates Foundation: Grant Investigator , Research support

S. Jones, Bill and Melinda Gates Foundation: Grant Investigator , Research support

K. Klugman, Bill and Melinda Gates Foundation: Investigator , Research support

M. Nunes, Bill and Melinda Gates Foundation: Grant Investigator , Research support

S. Madhi, Bill and Melinda Gates Foundation: Grant Investigator , Grant recipient and Research support

See more of: Vaccines: Influenza
See more of: Poster Abstract Session
Previous Abstract | Next Abstract >>

Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.