1771. Effect of chlorhexidine (CHG) bathing and universal contact isolation on carbapenem-resistant Acinetobacter baumannii (CRAB) infection or colonization in a medical intensive care unit (MICU)
Session: Poster Abstract Session: Resistant Gram-Negative Infections: Acinetobacter
Saturday, October 10, 2015
Room: Poster Hall

Background: There are few data about the impact of daily CHG bathing and universal contact isolation on the decrease in the rate of CRAB infection or colonization, compared with this strategy for MRSA or VRE.

Methods: This study was conducted at a 13-bed MICU from Oct-2012 through Oct-2014. During the 12-month baseline period, active surveillance for CRAB at ICU admission or weekly during the ICU stay, contact precaution, and environmental cleaning were implemented. Because the number of CRAB isolates were increasing despite of performing of these programs, daily CHG bathing for all ICU patients and universal contact isolation were introduced since Oct-2013. The monthly incidence of CRAB was estimated as the number of isolation of CRAB from clinical cultures performed more than 48 hours after ICU admission per 1,000 patient-days (PD). Changes in the incidence of CRAB infection or colonization before and after CHG bathing protocol and universal contact isolation were analyzed using an interrupted time series (ITS) analysis (segmented Poisson regression). The introductory month (Oct-2013) was not included in the analysis.

Results: The incidence of CRAB was 6.19 per 1,000 PD in the baseline period, and 8.63 per 1,000 PD in the intervention period (P = 0.16). However, ITS analysis showed a significant change in the slope (b, -0.50 [95% CI, -0.74 to -0.27]; P < 0.01) and an insignificant change in the level (b, -0.39 [95% CI, -1.34 to 0.56]; P= 0.42) of CRAB incidence after the implementation of CHG bathing and universal contact isolation (Figure 1). 

Conclusion: Our study supports daily CHG bathing and universal contact isolation to decrease CRAB infection or colonization in a MICU.

Oh-Hyun Cho, MD1, Ki-Ho Park, MD2, Wonyong Jo, MD3, Eun Hwa Baek, RN4, Mi Hui Bak, RN4 and In-Gyu Bae, MD5, (1)Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, South Korea, (2)Division of Infectious Diseases, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, South Korea, (3)Department of Internal Medicine, Gyeongsang National Univesity Hospital, Jinju, South Korea, (4)Infection Control Office, Gyeongsang National University Hospital, JinJu, South Korea, (5)Division of Infectious Diseases Department of Internal Medicine, Gyeongsang National University Hospital, JinJu, South Korea

Disclosures:

O. H. Cho, None

K. H. Park, None

W. Jo, None

E. H. Baek, None

M. H. Bak, None

I. G. Bae, None

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