1047. Factors Affecting Mortality in Hepatitis with pregnancy - A Study from North India
Session: Poster Abstract Session: Hepatitis Viruses
Friday, October 9, 2015
Room: Poster Hall
Background:

Pregnancy is a high risk condition for mortality during acute phase of hepatitis as compared to the non-pregnant state. This study was conducted aiming to identify the factors affecting mortality in pregnant women with hepatitis in a tertiary care hospital in North India.

Methods:

A case control study was conducted at Maulana Azad Medical College, New Delhi, India. Data of pregnant women admitted with hepatitis, in the past 10 years (January 2005 to December 2014) was collected. All women who died during the hospital stay (a total of 24 women) constituted the cases and those who survived constituted the controls. Hundred controls were selected by stratified random sampling taking 10 subjects from each of the 10 years. Factors that could affect the mortality were documented and analysed by logistic regression.

Results: Hepatitis E and B were the commonest types among cases and controls respectively. Mortality occurred within 5 days of admission in 91.6%  and 33.2%  died undelivered. 

Conclusion: Among the factors studied, low socio economic status, Hepatitis E and coagulopathy were contributing to the mortality. Other factors like low immunity and hormonal changes which may affect viral replication during pregnancy need to be studied.

 

Survival

(n1=100)

Mortality

(n2=24)

P-value

Unadjusted Odds ratio

(95% CI)

Adjusted Odds ratio

(95% CI)

Age

24.2±3.5

24.2±4.3

0.998

 

 

Socio Economic Status

Low Middle

Upper Lower

Lower

43 (43.0%)

31 (31.0%)

26 (26.0%)

3 (12.5%)

10 (41.7%)

11 (45.8%)

0.012

1.0

4.62 (1.17 to 18.20)

6.06 (1.54 to 23.77)

1.0

4.02 (0.77 to 20.92)

20.73 (3.11 to 138.38)

HepA

Absent

Present

81 (81.0%)

19 (19.0%)

24(100.0%)

0

0.023

1.0

Omitted

-

HepB

Absent

Present

53 (53.0%)

47 (47.0%)

18 (75.0%)

6 (25.0%)

0.050

1.0

0.37 (0.13 to 1.02)

-

HepC

Absent

Present

94 (94.0%)

6 (6.0%)

22 (9.7%)

2 (8.3%)

0.651

1.0

1.42 (0.26 to 7.51)

-

HepE

Absent

Present

72 (72.0%)

28 (28.0%)

8 (33.3%)

16 (66.7%)

<0.001

1.0

5.14 (1.98 to 13.35)

1.0

5.84 (1.60 to 21.27)

Anemia

Absent

Present

72 (72.0%)

28 (28.0%)

14 (58.3%)

10 (41.7%)

0.192

1.0

1.86 (0.73 to 4.61)

-

Diabetes

Absent

Present

94 (94.0%)

6 (6.0%)

22 (97.7%)

2 (8.3%)

0.676

1.0

1.42 (0.27 to 7.53)

-

Coagulopathy

Absent

Present

89 (89.0%)

11 (11.0%)

9 (37.5%)

15 (62.5%)

<0.001

1.0

13.48 (4.78 to 38.03)

1.0

13.09 (3.60 to 47.59)

Encephalopathy

Absent

Present

100(100.0%)

0

15 (62.5%)

9 (37.5%)

<0.001

1.0

Omitted

-

 CI=Confidence Interval

Niharika Yedla, MBBS1, Nikita Banerjee, MD2, Reva Tripathi, MD2 and Bratati Banerjee, MD3, (1)Maulana Azad Medical College, New Delhi, India, (2)Department of Obstetrics, Maulana Azad Medical College, New Delhi, India, (3)Department of Community Medicine, Maulana Azad Medical College, New Delhi, India

Disclosures:

N. Yedla, None

N. Banerjee, None

R. Tripathi, None

B. Banerjee, None

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