1640. High Prevalence Rickettsia spp. Infection among  Patients with Acute Undifferentiated Fever in Southern Thailand and First Report of Rickettsia felis Infection
Session: Poster Abstract Session: Global Health
Saturday, October 10, 2015
Room: Poster Hall
Background: Rickettsia spp. is a major causes of acute undifferentiated fever (AUF) in Thailand. Scrub and murine typhus, caused by Orientia tsutsugamushi and Rickettsia typhi, respectively, are important acute febrile illnesses in Thailand. While the data of other Rickettsia spp. and Bartonella spp.was unknown

Methods: We prospectively evaluated two real-time polymerase chain reaction (PCR) assays and  seroconversion of  IgG Antibody   for  Rickettsia spp. and Bartonella spp. infection among the patients with AUF in Southern Thailand from January 2013 to December 2014.

Results: Of 150 patients with AUF, 40 (26.7%) patients had seroconversion of Rickettsia spp.  infection while there  was no seroconversion for Bartonella spp. infection. By seroconversion , 7.3% (11 of 150) and 18 % (27 of 150) of patients were confirmed to have  scrub or murine typhus, respectively. There was 2 patients had unidentified specific antibody for Rickettsia spp. infection. The PCR assays for the detection of O. tsutsugamushi and Rickettsia spp. had high sensitivity and specificity (97.5 % [95% confidence interval (CI): 95.2–100] and 100% [95% CI: 97.8–100], respectively). For those 2 patients,  a PCR to detect the gltA of the Rickettsia feliswere positive in  their acute serum. The PCR products  were also  confirmed with sequencing analysis.  

Conclusion: Orientia tsutsugamushi and Rickettsia typhi were the major causes of Rickettsia spp. infection in southern Thailand. This is the first report of R. felis infection in human from southern Thailand. Surveillance for Rickettsia spp. is  needed due to the emergence of  novel species.

Sarunyou Chusri, MD, PhD, Internal Medicine, Faculty of Medicine , Prince of Songkla University, Hatyai, Thailand, Khachornsakdi Silpapojakul, M.D., Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand and Butsaya Thaisomboonsuk, PhD, Armed Fources Institute of Medical Science, Bangkok, Thailand

Disclosures:

S. Chusri, None

K. Silpapojakul, None

B. Thaisomboonsuk, None

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