735. Comparative Antimicrobial Efficacy of Two Hand-Hygiene Products in Intensive Care Units (ICU): A Randomized Controlled Trial
Session: Oral Abstract Session: Preventing Hospital Transmission: Environment and Hands
Friday, October 9, 2015: 11:30 AM
Room: 7--AB
Background: Contaminated hands of healthcare workers (HCW) are an important source of transmission of healthcare associated infections in the ICU.  Alcohol based hand rubs (ABHR), the primary form of hand hygiene in healthcare settings, are effective but do not provide sustained antimicrobial activity.  The aim of this study was to compare the antimicrobial efficacy of two hand hygiene products (a 1% chlorhexidine (CHG) + 61% alcohol handrub and a non-aerosol foaming ABHR containing 70% alcohol) to determine if the CHG + alcohol hand antiseptic will provide more sustained antimicrobial protection.

Methods: A prospective randomized clinical trial with crossover design, paired data, and blind evaluation was done in three medical ICUs in a large academic teaching hospital. Eligible personnel included permanent and temporary HCWs involved with direct patient care in the ICU. HCWs were randomly assigned to one of two hand hygiene products using a crossover design. Hand hygiene was performed after patient care.  Hand prints were obtained immediately after hand hygiene was performed and again after spending > 5 minutes in the ICU common areas. The numbers of aerobic colony-forming units (CFU) were compared for the two groups after log transformation.

Results: A total of 51 HCWs completed testing of both products. On bare hands, use of CHG + alcohol was associated with significantly lower recovery of aerobic CFU, both immediately after use (0.27±0.38 and 0.88±0.55 log10 CFU; P=.035) and after spending time in the ICU common areas (1.81±0.48 and 2.17±0.35 log10 CFU; P<.0001). Both of the antiseptics were well tolerated by HCWs with no adverse events. 

Conclusion: The CHG + alcohol product was associated with significantly lower aerobic bacterial counts on hands of healthcare personnel, both immediately after use and after spending time in ICU common areas. Further studies are needed to determine if the use of the CHG + alcohol product results in sustained antimicrobial protection against healthcare-associated pathogens on hands of HCW.

Abhishek Deshpande, MD, PhD1,2, Jacqueline Fox, RN1, Ken Koon Wong, MD2, Sarah Schramm, MA1, Curtis J. Donskey, MD3, Thomas G. Fraser, MD, FSHEA2 and Steven Gordon, MD, FIDSA, FSHEA2, (1)Medicine, Cleveland Clinic, Cleveland, OH, (2)Infectious Disease, Cleveland Clinic, Cleveland, OH, (3)Infectious Disease, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH


A. Deshpande, 3M: Investigator , Research support

J. Fox, None

K. K. Wong, None

S. Schramm, None

C. J. Donskey, 3M: Scientific Advisor , Consulting fee

T. G. Fraser, None

S. Gordon, 3M: Scientific Advisor , Consulting fee

Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.