831. Clinical Characteristics of Group D Streptococcal Bacteremia in a University Hospital in Thailand
Session: Poster Abstract Session: Bacteremia and Endocarditis
Friday, October 9, 2015
Room: Poster Hall
Posters
  • GDS Poster_ID week 2015 PDF.pdf (111.1 kB)
  • Background: Group D streptococci (GDS) are indigenous in the gastrointestinal tracts of humans and animals. Currently, S. bovis, the most common GDS, has been re-classified into 4 different species (Streptococcus gallolyticus, Streptococcus pasteurianus, Streptococcus infantarius and Streptococcus lutetiensis). However, clinical characteristics and the association between gastrointestinal diseases and these species have not been well studied. The objective of this study is to investigate the clinical characteristics of patients with GDS bacteremia.

    Methods: We conducted a retrospective review of adult patients with GDS bacteremia who were hospitalized at Siriraj Hospital between 1 January 2009 to 30 June 2011. Clinical characteristics including predisposing factors and microbiological data were analyzed.

    Results: One hundred and forty-seven episodes of bacteremia caused by GDS were included. Seventy-eight patients (58.2%) were male. Patients’ mean age was 63 years. Of 147 GDS isolates, 134 (91.2%) were identified as S. pasteurianus, 6 (4.1%) were S. gallolyticus, 2 (1.4%) were S. infantarius, 1 (0.7%) were S. lutetiensis and 4 isolates (2.7%) were unidentifiable. Cirrhosis was identified as underlying disease in 87 patients (59.2%). Eighty-three patients (56.5%) had primary bacteremia and 49 patients (33.3%) had secondary bacteremia from spontaneous bacterial peritonitis. Thirty patients (20.9%) underwent colonic evaluation and colonic polyps were the most common finding found in 8 patients. Colonic cancer was diagnosed in 5 patients with GDS bacteremia in which 4 of 5 patients were diagnosed previously and before the bacteremic episodes. Bacteremia due to S. pasteurianus was associated with patients who had cirrhosis (p = 0.041), whereas S. gallolyticus was more likely to be associated with non-cirrhotic patients (p = 0.031). Overall mortality of patients with GDS bacteremia was 22%.

    Conclusion: S. pasteurianus was the most common species isolated in patients with GDS bacteremia and is associated with chronic liver disease.

    Methee Chayakulkeeree, MD, PhD1, Papatsakorn Nopjaroonsri, MD1 and Amornrut Leelaporn, PhD2, (1)Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, (2)Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Disclosures:

    M. Chayakulkeeree, None

    P. Nopjaroonsri, None

    A. Leelaporn, None

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