968. Attitudes Toward Fecal Microbiota Transplantation Among Patients with C. difficile
Session: Poster Abstract Session: Clostridium difficile Infections: Treatment and Prevention
Friday, October 9, 2015
Room: Poster Hall
  • Drees_FMT patient survey_IDWeek2015poster_FINAL.pdf (887.6 kB)
  • Background:   Widespread adoption of fecal microbiota transplantation (FMT) for recurrent Clostridium difficile infection (CDI) has been limited due to acceptance, logistic and regulatory issues.  Prior to launching an FMT program at our institution, we surveyed patients who had been hospitalized with CDI to assess their attitudes about and potential acceptance of FMT.

    Methods:   We surveyed patients who had been diagnosed with at least 1 episode of CDI as inpatients at our >1100-bed academic community-based healthcare system during 2013-2014.  The survey  was administered by telephone after discharge, and ascertained current knowledge about FMT and its effectiveness, acceptance of FMT should they have another episode, preference for transplantation method and donor type (anonymous vs. known to them), and ability to find a donor.

    Results:   Of 155 patients surveyed, the majority (71%) had had 1 episode of CDI, 20% had had 2 episodes, and 9% had had 3 or more CDI episodes at the time of the survey.  Most (72%) were unfamiliar with the term “fecal transplant.”  After a brief description of FMT and its effectiveness, 23% thought that ideal timing of FMT would be after 1 episode of CDI to prevent any recurrences, while 13% thought after 2 episodes; only 7% thought FMT should never be done.  Nearly half (43%) would prefer a donor known to them, while 10% preferred an anonymous donor and the rest had no preference or were unsure.  While most (60%) stated they would be able to find a donor, nearly 25% stated they would not be able to find one or would find it very difficult to ask someone to donate stool.   One third would prefer to receive their FMT by colonoscopy, with 14% preferring enema and only 2% preferring nasogastric administration.  Overall, 57% stated that they would probably or definitely consider FMT if they had another episode of CDI.

    Conclusion:  In a series of patients suffering from at least 1 episode of CDI requiring hospitalization, the majority were potentially interested in FMT should they have a recurrence.  More patients preferred a stool donor known to them than an anonymous donor.

    Marci Drees, MD, MS1,2,3, Patty Mcgraw, RN, MS3, Boniface Fogwe, BS3, Alfred E. Bacon III, MD3 and Chad Duffalo, MD, MPH3, (1)Value Institute, Christiana Care Health System, Newark, DE, (2)Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, (3)Christiana Care Health System, Newark, DE


    M. Drees, None

    P. Mcgraw, None

    B. Fogwe, None

    A. E. Bacon III, None

    C. Duffalo, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.