417. Presenting with AIDS at Diagnosis is Associated with 24-month Viral Suppression in Patients Newly Diagnosed with HIV During Hospitalization at an Urban Hospital Center
Session: Poster Abstract Session: HIV Clinical Practice Issues: Cost-Effectiveness, Long-Term Outcomes
Thursday, October 8, 2015
Room: Poster Hall
Background: HIV testing during hospitalization has been recommended by CDC for many years yet little is known about the outcomes of patients diagnosed in the hospital. We aimed to characterize patient-level and system-level factors associated with long-term viral suppression (VS) following an inpatient HIV diagnosis.

Methods: Retrospective cohort study in patients newly diagnosed during hospitalization at Grady Memorial Hospital in Atlanta, GA from January 2011 - December 2012.  Data were abstracted from medical records and the Georgia Department of Public Health Enhanced HIV/AIDS Surveillance System (eHARS) for 24 months following the diagnosis. Primary outcome was 24-month VS, defined as the last HIV-1 RNA of each 12-month period after diagnosis being <200 copies/mL. Variables with significance (p<0.05) by univariate analyses and epidemiologically significant factors were included in a backward multivariate logistic regression analysis.

Results: 132 patients were newly diagnosed during the study period. Median age was 41 (IQR 31, 51), 77% men, 77% non-Hispanic Black, 75% uninsured, 18% homeless, and 13% crack/cocaine users. At diagnosis the median CD4 was 83 cells/µL (IQR 18, 264), 42% had an AIDS-defining opportunistic infection (OI) and 70% had AIDS (CD4 < 200 cell/µL or presence of an OI).  46% linked to the same healthcare system outpatient clinic (IDP) and 24% linked elsewhere in GA (by state labs) within 90 days of hospital discharge.  49 (37%) patients achieved 24-month VS. In univariate analyses, AIDS and being a man who had sex with men (MSM) were associated with 24-month VS while age ≥ 50 and cocaine use were significantly associated with not achieving 24-month VS. In a multivariate analysis having AIDS (OR 3.93, 95% CI 1.43-10.76) and being MSM (OR 2.58, 95% CI 1.08-6.18) remained significant and were associated with 24-month VS. 

Conclusion: Most patients with new diagnoses during hospitalization still present with advanced HIV. AIDS at diagnosis was most strongly associated with achieving long-term VS for two years after inpatient diagnoses. These data suggest that patients have better virologic outcomes when they are diagnosed with advanced HIV, which may be mediated by their eligibility for a Ryan White funded clinic (IDP) with robust wrap around services and/or by patients’ perception of their own illness.

Jonathan Colasanti, MD, MSPH1, Neela D. Goswami, MD1, Jakob Khoubian, MD2, Eugene Pennisi, MA, MPH3, Wendy Armstrong, MD, FIDSA1 and Carlos Del Rio, MD, FIDSA1,4, (1)Medicine (Infectious Diseases), Emory University, Atlanta, GA, (2)Emory University School of Medicine, Atlanta, GA, (3)Georgia Department of Public Health, Atlanta, GA, (4)Global Health, Emory University Rollins School of Public Health, Atlanta, GA

Disclosures:

J. Colasanti, None

N. D. Goswami, None

J. Khoubian, None

E. Pennisi, None

W. Armstrong, None

C. Del Rio, IAS-USA: Board Member , Volunteer Board member

<< Previous Abstract | Next Abstract

Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.