1060. HPV-Associated Cancers in Women: Multivariable Survival Analysis of Population-Based Florida Cancer Registry (1981-2009)
Session: Poster Abstract Session: Herpesviruses, HPV, and Other Viruses
Friday, October 9, 2015
Room: Poster Hall
Posters
  • IDweek 2015_53212_HPVAssociated Cancers in Women Survival_ErinFinal.pdf (499.0 kB)
  • Background: HPV is associated with most oropharyngeal, cervical, anal cancers and almost half of all vaginal and vulvar cancers. Compared to other states, Florida has one of the highest HPV-associated oropharyngeal, cervical and anal cancer rates in women, mid-level rates of HPV-associated vaginal cancer, and one of the lowest rates of HPV-associated vulvar cancer. We report HPV-associated cancer burden among Floridian women (≥18yrs) across race, ethnicity, neighborhood poverty status (NPS), and smoking status.

    Methods: Data from Florida Cancer Data System (1981-2009) was linked with US census to explore survival by demographic characteristics for HPV-associated cancers. Survival was compared by race, ethnicity, and NPS. Multivariable Cox regression were used to obtain hazard ratio (HR) and 95% confidence interval (95%CI). Overall survival is calculated by elapsed time from cancer diagnosis to death or last contact for living patients.

    Results: There were 39,272 cervical, 10,106 vulvar, 4,398 anal, 4,017 tongue, 2,264 vaginal, and 1,841 tonsil cancer cases in Floridian women from 1981-2009. Median survival times varied from 2.1yrs-5.2yrs depending on cancer type: vulvar 5.2yrs (95%CI:4.9-5.4), cervical 3.5yrs (3.4-3.7), vaginal 2.7yrs (2.4-2.9), anal 2.7yrs (2.6, 2.9), tonsil 2.4yrs (2.1-2.6), and tongue 2.1yrs (1.9-2.2). Blacks had higher mortality compared to Whites for cervical (HR=[1.2]; 95%CI: 1.1-1.3), anal ([1.3]; 1.2-1.5), tongue ([1.4]; 1.1-1.7), and tonsil ([1.3]; 1.1-1.6). Compared to never smokers, current and former smokers had higher mortality for tongue (current [1.2]; 1.1-1.4 and former [1.1]; 1.0-1.3) and tonsil (current [1.5]; 1.3-1.9 and former [1.3]; 1.1-1.6) cancers but not vulvar cancer (current [0.7]; 0.6, 0.7). Hispanics had higher cervical cancer mortality than non-Hispanics ([1.1]; 1.0-1.1). Highest NPS had better vaginal cancer survival compared to lowest ([0.7]; 0.6-0.9).

    Conclusion:  As HPV is the most common sexually transmitted infection in the US, understanding survival disparities in women for HPV-associated cancers is important. These results may be used to design culturally competent cancer screening and prevention programs via HPV vaccination efforts and health promotion for Floridian women.

    Erin Dunn, BA1, Kevin J. Moore, BA1, Feng Miao, MS2 and Tulay Koru-Sengul, PhD2, (1)Medical Education (MD/MPH program) and Department of Pubic Health Sciences, University of Miami Miller School of Medicine, Miami, FL, (2)Department of Public Health Sciences, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

    Disclosures:

    E. Dunn, None

    K. J. Moore, None

    F. Miao, None

    T. Koru-Sengul, None

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