246. Usefulness of Non Invasive Fibrosis Markers in the Assessment of Chronic Hepatitis B
Session: Poster Abstract Session: Diagnostics: Miscellaneous
Thursday, October 8, 2015
Room: Poster Hall
Posters
  • P 246.pdf (71.4 kB)
  • Background: Chronic hepatitis B viral (CHB) infection remains frequent in developing countries. It may lead to cirrhosis and/or hepatocellular carcinoma. Liver biopsy is expensive and risky which often requires hospitalization. We aim to evaluate the usefulness of the aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 score (FIB-4) in predicting liver fibrosis in CHB.

    Methods: A retrospective study included all patients with CHB followed in a department of Infectious Diseases from 2005 to 2015. They underwent biological analysis and liver biopsy. A severe fibrosis was defined when Metavir-Score was ≥ F2.

    Results: One hundred and twenty patients were enrolled. They were predominantly men (70%). Mean age was 37.4 ± 10 years. Family history of hepatitis B was found in 26 patients (21.7%). Fifty three patients (44%) had no symptoms and 39 ones (32.4%) had abnormal abdominal echographic findings. Regarding the histological results, we gathered 64 patients with severe fibrosis. According to Metavir scoring system, 52 patients (43.3%) had F1 stage and 42 ones had F2 stage. Metavir F3 stage was encountered in 18 patients (15%) and only 4 patients had F4 stage (3.3%). Both APRI and FIB-4 scores were significantly greater in patients with severe liver fibrosis (1.28±1.8 vs. 0.49±0.27; p< 0.001 and 2.14±3 vs. 1±0.5; p<0.001 respectively). The area under receiver operating characteristic curve (AUROC) for predicting severe fibrosis was 0.72 with APRI score and 0.71 with FIB-4 score. An APRI threshold of 0.5 was 70% sensitive and 69% specific while FIB-4 had lower levels (sensitivity = 64% and specificity = 62%) at a threshold of 1.

    Conclusion: Our study highlighted that non-invasive fibrosis markers seem to be interesting in CHB. They had a significant correlation with histological findings. APRI score had better sensitivity and specificity than FIB-4 to predict severe fibrosis in CHB.

    Houda Ben Ayed, MD1, Makram Koubaa, MD1, Asma Tlijani, MD1, Tarak Ben Jemaa, MD1, Sahar Ben Kahla, MD1, Chakib Marrakchi, MD1, Rim Marrakchi, MD2, Kamel Jamoussi, MD2 and Mounir Ben Jemaa, MD1, (1)Department of Infectious Diseases, Hedi Chaker University Hospital, Sfax, Tunisia, (2)Department of Biochemistry, Hedi Chaker University Hospital, Sfax, Tunisia

    Disclosures:

    H. Ben Ayed, None

    M. Koubaa, None

    A. Tlijani, None

    T. Ben Jemaa, None

    S. Ben Kahla, None

    C. Marrakchi, None

    R. Marrakchi, None

    K. Jamoussi, None

    M. Ben Jemaa, None

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