1590. Etiology of Pneumonia in United States Military Recruits
Session: Poster Abstract Session: Community Acquired Pneumonia
Saturday, October 10, 2015
Room: Poster Hall
  • Poster - pneumonia -IDWeek 2015.pdf (1.2 MB)
  • Background: Pneumonia affects people of all ages worldwide. While it is a leading cause of death among children, the elderly, and immunocompromised individuals, it presents a significant risk to healthy young adults, particularly in crowded and stressful environments. We sought to investigate the etiology of pneumonia cases in young healthy adults undergoing US military recruit training.

    Methods: Clinical and laboratory data were collected from subjects diagnosed with pneumonia from four U.S. military recruit camps between February 2004 and January 2015. Serum, throat swabs, and nasopharyngeal swabs were tested for a variety of respiratory pathogens, including adenovirus, influenza A and B viruses, parainfluenza viruses (PIV) 1–3, enterovirus, herpes simplex virus (HSV), respiratory syncytial virus, Mycoplasma pneumoniae, Streptococcus pneumoniae, Chlamydophila pneumoniae, Bordetella pertussis, and Legionella pneumophila.  Additionally, positivity rates among those tested were compared during the pre-(2004-2011) and post- adenovirus vaccines (2012-2015) periods.

    Results: During the 11 years of this study, 2355 individuals with pneumonia were enrolled.  The most commonly detected pathogen was adenovirus (36%), followed by M. pneumoniae (35%), rhinovirus (34%), C. pneumoniae (20%), S. pneumoniae (7%), enterovirus (3%), HSV (2%), influenza A (2%) and PIV 3 (1%).  Co-infections among adenovirus, M. pneumoniae, and C. pneumoniae were common, with 4-12% of cases being positive for two pathogens and 3% having all three.  Differences in pathogen distribution were noted after the adenovirus vaccines were resumed, most notably a precipitous decline in adenovirus infections.

    Conclusion: Adenovirus, M. pneumoniae, rhinovirus, and C. pneumoniae were the major contributing pathogens in young adults diagnosed with pneumonia at military training sites, and may be relevant to pneumonia epidemiology in other institutional settings containing young adults.

    Jennifer Radin, PhD, MPH, Christian Hansen, BS, Anthony Hawksworth, BS and Rachel Lee, MD, Operational Infectious Diseases, Naval Health Res. Ctr., San Diego, CA


    J. Radin, None

    C. Hansen, None

    A. Hawksworth, None

    R. Lee, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 7th with the exception of research findings presented at the IDWeek press conferences.