1057. Multivariable Survival Analysis of Male Anal Cancer: Implications for HPV Screening and Prevention Strategies
Session: Poster Abstract Session: Herpesviruses, HPV, and Other Viruses
Friday, October 9, 2015
Room: Poster Hall
Posters
  • IDweek 2015_53257_MultivariableSurvivalAnalysis_MaleAnalCancer_final.pdf (386.8 kB)
  • Background: HPV infection is associated with over 90% of anal cancers in men, and Florida has one of the highest rates of HPV-associated anal cancer in the US. Over the past ten years, male anal cancer incidence has been increasing across the country. Statewide population-based cancer registries provide prevalence, trend, and determinant data to identify disparities in the burden and survival of anal cancer. Identifying subgroups that carry the greatest burden for anal cancer should be targeted for HPV screening and prevention.

    Methods: Data from the Florida Cancer Data System (1981-2009) was linked with US census to explore median survival by demographics characteristics for male anal cancer. Survival was compared by race, ethnicity, and socioeconomic status (SES). Multivariable Cox regression models were used to obtain hazard ratio (HR) and 95% confidence interval (95%CI). Overall survival time is calculated by the elapsed time from anal cancer diagnosis to death or last contact for alive patients.

    Results: There were 2,855 Florida adult men diagnosed with anal cancer. The majority were White (90.8%), non-Hispanic (89.0%), and living in an urban area (94.2%). The greatest proportion of those diagnosed was from the neighborhood with lowest SES (18.8%), while the smallest proportion was from the highest SES (14.1%). The overall median survival time was 2.3 years (95%CI: 2.2, 2.5). White race showed a longer median survival time (2.4 years) than Black race (1.8 years). The lowest SES status had the shortest median survival time at 1.9 years (1.6, 2.3), while the highest SES had the longest (2.6 years; 1.8, 3.3). Compared to Whites, Blacks (HR=[1.19];95%CI:0.96, 1.47) and Other race ([1.35]; 0.79, 2.3) showed worse survival. Although not statistically significant, current smokers showed slightly better survival ([0.98]; 0.85, 1.14) when compared to those who had never smoked.

    Conclusion: Based on the data and models, it is evident that there are disparities across races, SES status, and smoker status for male anal cancer prevalence and survival. Due to the link between HPV and anal cancer, it is important for HPV screening and prevention programs to target the groups with the highest burden of anal cancer prevalence and mortality.

    Kevin J. Moore, BA1, Erin Dunn, BA1, Feng Miao, MS2 and Tulay Koru-Sengul, PhD2, (1)Medical Education (MD/MPH program) and Department of Pubic Health Sciences, University of Miami Miller School of Medicine, Miami, FL, (2)Department of Public Health Sciences, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

    Disclosures:

    K. J. Moore, None

    E. Dunn, None

    F. Miao, None

    T. Koru-Sengul, None

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