Methods: Data from the Florida Cancer Data System (1981-2009) was linked with US census to explore median survival by demographics characteristics for male anal cancer. Survival was compared by race, ethnicity, and socioeconomic status (SES). Multivariable Cox regression models were used to obtain hazard ratio (HR) and 95% confidence interval (95%CI). Overall survival time is calculated by the elapsed time from anal cancer diagnosis to death or last contact for alive patients.
Results: There were 2,855 Florida adult men diagnosed with anal cancer. The majority were White (90.8%), non-Hispanic (89.0%), and living in an urban area (94.2%). The greatest proportion of those diagnosed was from the neighborhood with lowest SES (18.8%), while the smallest proportion was from the highest SES (14.1%). The overall median survival time was 2.3 years (95%CI: 2.2, 2.5). White race showed a longer median survival time (2.4 years) than Black race (1.8 years). The lowest SES status had the shortest median survival time at 1.9 years (1.6, 2.3), while the highest SES had the longest (2.6 years; 1.8, 3.3). Compared to Whites, Blacks (HR=[1.19];95%CI:0.96, 1.47) and Other race ([1.35]; 0.79, 2.3) showed worse survival. Although not statistically significant, current smokers showed slightly better survival ([0.98]; 0.85, 1.14) when compared to those who had never smoked.
Conclusion: Based on the data and models, it is evident that there are disparities across races, SES status, and smoker status for male anal cancer prevalence and survival. Due to the link between HPV and anal cancer, it is important for HPV screening and prevention programs to target the groups with the highest burden of anal cancer prevalence and mortality.
K. J. Moore,
F. Miao, None
T. Koru-Sengul, None