985. A spatial analysis of Community-acquired Meningitis in Adults in Houston, Texas 
Session: Poster Abstract Session: CNS Infection
Friday, October 9, 2015
Room: Poster Hall
Background: Community-acquired meningitis can be caused by viral, bacterial, fungal and mycobacterial pathogens. Some of this entities may occur in epidemics, have a seasonal pattern or occur in areas of high population density and poverty. In this study, we describe the spatial distribution of meningitis cases in Houston, TX and its surroundings, and visualize the relevant spatial patterns that can aid in targeting high risk areas for surveillance and preventive efforts. Methods: Our study region includes Harris and its 12 neighboring counties. Secondary data was collected from 8 Memorial Hermann hospitals from Houston and its surrounding areas from January 2005 until January 2010. A total of 604 confirmed cases of meningitis representing 165 zip codes across the study region were included in the analysis. The unit of analysis was patient zip codes. The zip codes were geocoded using the Google Geocoding API V3 service Stata 13.0 and ArcView GIS v3.2a (Environmental Systems Research Institute, Inc., Redlands, CA). Spatial autocorrelation analysis was done using Global Moran`s Index, and local disease clusters were identified by calculating the Local Indicator of Spatial Correlation (LISA) statistic. Results: A total of 604 cases of meningitis were identified: 81 (13.4%) were due to viruses, 51 (8.4%) were due to fungal pathogens, and 30 (5%) were due to bacterial meningitis. A diagnosis was not found in 442 (73%) of the patients. Approximately one-third of patients (197) were uninsured and 81 (13.4%) had HIV infection. Preliminary results suggest that within the study region, high number of meningitis cases (range 7-13) were concentrated in the south and central regions of the Harris County. Conclusion: Exploring spatial variation and patterns of meningitis cases can help identify spatial risk factors, and direct attention towards high-risk vulnerable areas with unmet health needs. Future plans of this study is to explore the correlation of occurrence of meningitis cases with environmental factors of seasonality and socio-economic status.
Kanika Mahajan, MPH, University of Texas, Houston, TX, Tarek Sulaiman, MD, UT Health, Houston, TX, Lucrecia Salazar, MD, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX, Susan Wootton, MD, Pediatrics, University of Texas Health Science Center, Houston, TX and Rodrigo Hasbun, MD, MPH, Infectious Diseases, University of Texas Health, Houston, TX

Disclosures:

K. Mahajan, None

T. Sulaiman, None

L. Salazar, None

S. Wootton, None

R. Hasbun, Medicine''s Company: Speaker's Bureau , Speaker honorarium
Cubist: Speaker's Bureau , Speaker honorarium
Theravance: Speaker's Bureau , Speaker honorarium
Pfizer: Speaker's Bureau , Speaker honorarium

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