Methods: Data from the Florida Cancer Data System (1981-2009) was linked with US census to explore median survival by demographic characteristics. Survival was compared by race, ethnicity, SES and smoking status. Multivariable Cox regression models were used to obtain hazard ratio (HR) and 95% confidence interval (95%CI). Overall survival time is calculated by the elapsed time from anal cancer diagnosis to death or last contact for alive patients.
Results: From 1981-2009, tongue and tonsil cancer were the most common HPV-associated cancers affecting 8,859 and 5,249 Florida males, respectively, then anal (2,855) and penile (2,148) cancers. Tongue cancer had the shortest median survival at 1.9 years (95%CI: 1.8, 1.9) then tonsil (2.1 yrs; 2.0, 2.2), anal (2.3 yrs; 2.2, 2.5), penile (3.5 yrs; 3.2, 3.8) cancers. Black showed higher mortality compared to White for penile (HR=[1.26];95%CI: 1.01, 1.56) and tongue ([1.59]; 1.41, 1.79) cancers. Other race had the higher mortality for tonsil ([1.40]; 0.79, 2.78) and anal ([1.35]; 0.79, 2.3) cancers. Among all SES statuses, highest SES status had the best survival for tonsil ([0.72]; 0.62, 0.83), penile ([0.77]; 0.62, 0.95), anal ([0.80]; 0.65, 0.98), tongue ([0.80]; 0.72, 0.89) cancers. Current smokers had significantly higher mortality for tongue ([1.37]; 1.25, 1.49) and tonsil ([1.41]; 1.24, 1.59) cancers.
Conclusion: In Florida, it is clear that there are disparities across races, SES status, and smoker status for male HPV-associated cancer prevalence and mortality. HPV is most commonly linked with cervical cancer in females; however, it is also important to identify and to address HPV-associated cancers in males. By identifying which groups carry the largest burden of HPV-associated cancers, we can establish group-specific screening and prevention efforts.
K. J. Moore,
F. Miao, None
T. Koru-Sengul, None