1058. Multivariate Survival Analysis of HPV-Related Cancers in Men: A Secondary Data Analysis from a Population-Based Cancer Registry
Session: Poster Abstract Session: Herpesviruses, HPV, and Other Viruses
Friday, October 9, 2015
Room: Poster Hall
Posters
  • IDweek 2015_53276_MultivariateSurvivalAnalysis_HPVmen_final.pdf (412.5 kB)
  • Background: HPV infection is linked with anal, tongue, tonsil, penile cancers in men. Prevalence and incidence of these HPV-associated cancers has increased over the past decade. Statewide population-based cancer registries provide data to identify burden and survival disparities of HPV-associated cancers in men. Identifying subgroups that carry the greatest burden for male HPV-associated cancers should be targeted for HPV screening and prevention.

    Methods: Data from the Florida Cancer Data System (1981-2009) was linked with US census to explore median survival by demographic characteristics. Survival was compared by race, ethnicity, SES and smoking status. Multivariable Cox regression models were used to obtain hazard ratio (HR) and 95% confidence interval (95%CI). Overall survival time is calculated by the elapsed time from anal cancer diagnosis to death or last contact for alive patients.

    Results: From 1981-2009, tongue and tonsil cancer were the most common HPV-associated cancers affecting 8,859 and 5,249 Florida males, respectively, then anal (2,855) and penile (2,148) cancers.  Tongue cancer had the shortest median survival at 1.9 years (95%CI: 1.8, 1.9) then tonsil (2.1 yrs; 2.0, 2.2), anal (2.3 yrs; 2.2, 2.5), penile (3.5 yrs; 3.2, 3.8) cancers. Black showed higher mortality compared to White for penile (HR=[1.26];95%CI: 1.01, 1.56) and tongue ([1.59]; 1.41, 1.79) cancers. Other race had the higher mortality for tonsil ([1.40]; 0.79, 2.78) and anal ([1.35]; 0.79, 2.3) cancers. Among all SES statuses, highest SES status had the best survival for tonsil ([0.72]; 0.62, 0.83), penile ([0.77]; 0.62, 0.95), anal ([0.80]; 0.65, 0.98), tongue ([0.80]; 0.72, 0.89) cancers. Current smokers had significantly higher mortality for tongue ([1.37]; 1.25, 1.49) and tonsil ([1.41]; 1.24, 1.59) cancers.

    Conclusion: In Florida, it is clear that there are disparities across races, SES status, and smoker status for male HPV-associated cancer prevalence and mortality. HPV is most commonly linked with cervical cancer in females; however, it is also important to identify and to address HPV-associated cancers in males. By identifying which groups carry the largest burden of HPV-associated cancers, we can establish group-specific screening and prevention efforts.

    Kevin J. Moore, BA1, Erin Dunn, BA1, Feng Miao, MS2 and Tulay Koru-Sengul, PhD2, (1)Medical Education (MD/MPH program) and Department of Pubic Health Sciences, University of Miami Miller School of Medicine, Miami, FL, (2)Department of Public Health Sciences, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

    Disclosures:

    K. J. Moore, None

    E. Dunn, None

    F. Miao, None

    T. Koru-Sengul, None

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