529. Burden of Acute Lower Respiratory Tract Infection Caused by Respiratory Syncytial Virus in Egypt
Session: Poster Abstract Session: Respiratory Infections: Viral (non Influenza)
Thursday, October 8, 2015
Room: Poster Hall
Posters
  • Poster Dr Amani El Kholy.JPG (3.1 MB)
  • Background:

    Respiratory syncytial virus (RSV) is one of the most important causes of acute lower respiratory tract infections (ALRTI) in infants and young children. RSV spreads readily causing nosocomial outbreaks and causes morbidity and mortality especially for high- risk groups. We aimed to assess the burden of ALRTI associated with RSV among children in Egypt using the Seegene multiplex PCR kits.

    Methods:

    We enrolled 3075 patients, of which 77.8% were children less than 5 years old diagnosed with ALRTI admitted to Cairo University Hospitals during five- year period from 2010 to 2014. Nasopharyngeal aspirates were obtained from the patients, and tested for RSV by Anyplex II RV 16 mutliplex PCR (Seegene, Korea). Thhe patients were followed- up till discharge from the hospital.

    Results:

    RSV was detected in 25.4% of children and 6.4% of adults. All the RSV positive children presented with cough and fever. More than 80% had tachypnea and nasal flare. Most cases were in the group less than one year of age (p< 0.01). Complications were associated with chronic lung and heart conditions (80% and 20% respectively). The most common complications were ARDS (81.8%), requiring ICU admission (12%) and death in 4.4%. Though seasonal distribution was not consistent, yet 90% of RSV cases occurred in winter and early spring seasons (p< 0.001). Predictors of prolonged hospital stay were: clinical presentation with lethargy (p = 0.008), cyanosis (p = 0.003), having any underlying chronic illness (p = 0.000), and having an underlying chronic cardiac disease (p = 0.021). Death occurred in 4.4% of cases.

    Conclusion:

    RSV is an important etiology of ALRTI in children below 5 years of age, especially in young infants below 12 months of age. As it is more prevalent in winter and tends to cause severe infection in high risk group, rapid diagnosis is essential and immunoprophylaxis should be considered in this group.

    Amani El Kholy, MD1, Nadia Mostafa, MD2, Nousa El Basha, MD2, May M. Sherif, MD3, Aliaa Adel, MD2, Mona Hamdy, MD4 and Ashraf Hatem, MD5, (1)Clinical Pathology, Cairo University Medical School, Cairo, Egypt, (2)Pediatrics, Cairo University, Cairo, Egypt, (3)Clinical Pathology, Cairo University, cairo, Egypt, (4)Clinical Pathology, Cairo University, Cairo, Egypt, (5)Chest Diseases, Cairo University, Cairo, Egypt

    Disclosures:

    A. El Kholy, None

    N. Mostafa, None

    N. El Basha, None

    M. M. Sherif, None

    A. Adel, None

    M. Hamdy, None

    A. Hatem, None

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