132. Comparison of IV Medication Administration Error Rates between Patients Prescribed Intermittent-Infusion vs. Extended-Infusion Piperacillin-Tazobactam
Session: Poster Abstract Session: Antimicrobial Stewardship: Adverse Drug Events
Thursday, October 8, 2015
Room: Poster Hall
Background: An extended-infusion (EI) piperacillin-tazobactam (PT) protocol was implemented on May 20th, 2013 at the University of Toledo Medical Center. The aim of this research was to investigate any potential difference in the rate of scheduled IV medication administration errors, excluding errors in PT administration, between patients receiving intermittent infusion (II) and EI PT at our facility.

Methods: Retrospective cohort analysis via chart review comparing IV medication administration error rates between patients who received II and EI PT therapy from August 2012 to February 2014. Eligible patients receiving PT prior to May 20th, 2013 (EI protocol implementation) were placed in II arm. Eligible patients receiving PT after that date were placed in EI arm. Data regarding demographic characteristics, duration of PT therapy and number of concomitant IV medications, administration errors (including: early or late doses, co-administration of incompatible medications, and missed doses), and the number and types of IV lines placed were collected and outcomes were compared between treatment arms.

Results: 498 patients screened; 199 patients included overall. 99 patients received II PT, 100 patients received EI PT. Excluded if receiving hemodialysis or no IV line documentation. All baseline characteristics were similar between groups except for median duration of PT therapy; 4 days in II group and 6 days in EI group (p=0.002). For primary endpoint (number of early or late errors/day of PT therapy) no difference was found between groups (0.125 errors/day for II and EI, p=0.882). For patients receiving EI PT with one IV line (single-lumen), median number of incompatibility errors per patient was greater compared to patients receiving II PT (2 vs. 0, respectively; p=0.004). No difference in the number of patients who experienced an early or late administration error was seen in these patients.

Conclusion: The implementation of a hospital-wide EI PT protocol does not appear, from these results, to have caused a significant change in the occurrence of medication administration errors for other scheduled IV medications. For patients with one IV line that has a single-lumen, errors in regards to compatibility may be increased with the use of EI PT.

Ethan Osborn, PharmD1, Kelli Cole, PharmD, BCPS1, Tyler Alverson, PharmD Candidate2, Cassius Hudson, PharmD Candidate2 and Todd Gundrum, PharmD, BCPS1, (1)University of Toledo Medical Center, Toledo, OH, (2)College of Pharmacy, The University of Toledo, Toledo, OH


E. Osborn, None

K. Cole, None

T. Alverson, None

C. Hudson, None

T. Gundrum, None

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