Methods: : A retrospective review of 18 cerebrospinal fluid (CSF) specimens submitted for CSF-VDRL analysis from October 2014 to May 2015 in patients suspected to have neurosyphilis was conducted. The feasibility of using EIA in place of CSF-VDRL was evaluated.
Results: Eighteen CSF specimens were included in the review. Thirteen (13) CSF were negative for CSF-VDRL and EIA. One CSF had a CSF-VDRL titer of 1:8; EIA was strongly positive at an index of 42.7. Four CSF specimens were negative for CSF-VDRL; all 4 specimens were positive for EIA with an index of 6.8, 12.2, 13.0 and 56.0. EIA index of <0.9 was considered negative; 0.9-1.09 was equivocal, and >1.1 was reported as positive.
Conclusion: These results show that EIA may be more sensitive than CSF-VDRL in the diagnosis of neurosyphilis. Further studies are ongoing to validate the use of EIA for the diagnosis of neurosyphilis.
E. A. Wong,
P. Long, None
H. Webb, None
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