Methods: Retrospective review of all positive ocular bacterial and fungal cultures submitted to the Bascom Palmer Eye Institute between January 2011- December 2013. Viral cultures were excluded. Cultures were categorized by source (anterior chamber, vitreous, cornea, conjunctiva) and antimicrobial susceptibilities by organism.
Results: 5626 ocular cultures were reviewed. 47% were positive. Most common isolates were 40% Gram negatives, 42% Gram positives, 8% molds 8%. Positive cultures by source were: 2279 (42%) cornea, 1173 (47%) conjunctiva, 243 (29%) anterior chamber, 534 (39%) vitreous/wash. The most common organisms isolated were Staphylococcus aureus 668 (21%), Pseudomonas aeruginosa 459 (37%), Streptococcus viridans 162 (12%), Serratia marcescens 126 (10%), Staph. epidermidis 120 (9%). From all gram negative isolates (n=1257) 8% were resistant to moxifloxacin, 6% to ciprofloxacin and 4% to levofloxacin, 7% were resistant to aminoglycosides. Methicillin resistance in gram positives was 44% for S.aureus and 62% for Staph.epidermidis. Only 40%% of Staphylococci were susceptible to fluoroquinolones in vitro.
Conclusion: Antimicrobial resistance is a global problem and ocular pathogens are not an exception. Our study shows an increase during the last decade of MRSA ocular infections with a high level of resistance to fluoroquinolones. Gram-negative infections were predominantly with Pseudomonas. Prudent use of antimicrobials for ocular prophylaxis and treatment of infections should be further investigated to preserve the efficacy of effective antimicrobials.
M. Tysiak, None
H. Flynn, None
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