A pre- and post-interventional study was conducted following the implementation of the Verigene BC-GN and BC-GP tests at 10 hospitals within a large community healthcare system. Data regarding demographic, microbiology, Verigene test results, initial and subsequent antibiotic therapy and clinical course were retrospectively collected. The primary outcome was the mean time to appropriate antibiotics. Secondary outcomes were duration of antibiotics for contaminants, length of stay, total admission costs, pharmacy charges, development of acute kidney injury, Clostridium difficile, mortality, and 30-day readmission rates.
A total of 431 patients (188 pre and 243 post-Verigene) were analyzed. Mean time to appropriate antibiotics was significantly lower in the post-Verigene group (42.6 versus 60.9 h, p<0.001), as were duration of antibiotics for contaminants (19.3 vs 63.0 h, p <0.001). Thirty day readmission rates were significantly lower in the post-Verigene group (14.0% vs 23.4%, p =0.016). There was a trend toward decreased C. difficile in the post-Verigene group (2.5% vs 5.3%, p=0.052). All other outcomes were similar between groups. Subgroup analyses consisting of 1) solely Gram positive isolates and 2) solely Gram negative isolates revealed a significant difference in mean time to appropriate antibiotics with the BC-GP (41.0 vs 65.1 h, p<0.001) but a non-significant difference with the BC-GN assay (45.9 vs 54.1 h, p =0.20). However, escalation of therapy was possible for several patients based on BC-GN results.
Conclusion: By decreasing the time to appropriate antibiotic therapy, the Verigene BC-GN and BC-GP tests can assist with antibiotic stewardship efforts in an inpatient community hospital setting.
W. Braun, None
J. Caranante, None
J. Moeller, None
L. Krop, None
J. Grey, None
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