1223. Bordetella pertussis infection in infants hospitalized for acute bronchiolitis
Session: Poster Abstract Session: Clinical Infectious Diseases: Respiratory Infections
Friday, October 28, 2016
Room: Poster Hall
Posters
  • Slayt1.GIF (264.9 kB)
  • Background: Acute bronchiolitis, which is one of the most common acute lower respiratory tract infections in infants, is primarily a viral disease. In recent studies using different detection methods, however, Bordetella pertussis (BP) has been detected in infants with acute bronchiolitis, as single or co-pathogen. The purpose of this study was to assess the frequency of Bordatella pertussis infection among infants hospitalized with acute bronchiolitis and to determine whether Bordetella pertussis infection effects on clinical course of acute bronchiolitis.

    Methods: This study was performed on 172 infants ≤ 6 months of age, who were hospitalized for acute bronchiolitis in Ege University Hospital. Bordatella pertussis was studied by a real-time polymerase chain reaction in nasopharyngeal aspirates. Viral etiology (adenovirus, rhinovirus, respiratory syncytial virus, parainfluenza virus, human bocavirus, influenza virus, human metapnomovirus and coronovirus) was also determined by PCR. Cases were divided into 2 groups according to BP-positive or BP-negative. Clinical parameters, clinical severity scores and laboratory characteristics were compared between the BP-positive or BP-negative cases.

    Results: A total of 172 infants were included in the study, 59.3 % were males. Overall, at least one pathogen was detected in 136/172 (81.4%) infants, of which RSV was the most prevalent detected in 89/172 (51.7%) infants. Bordetella pertussis involvement was found in 44 (25.6%) of the 172 infants hospitalized for viral bronchiolitis and 17 (9.8%) had only BP, as a sole pathogen. Of the 44 pertussis-positive infants, only 17 (38.6%) experienced a paroxysmal cough, 13 (29.5%) had whooping and 15 (34.1%) had post-tussive vomiting. There were no significant differences in the frequency of paroxysmal cough, whooping and post-tussive vomiting between the pertussis-positive and pertussis-negative infants. Clinical severity scores of pertussis-positive infants was similar with those of pertussis-negative infants (4.6 ± 1.8, 5.2 ± 2.5, respectively, p=0.123).

    Conclusion: Bordetella pertussis infection is common in young infants hospitalized for acute bronchiolitis mostly as a coinfection. The clinical features of pertussis in the infants are not characteristic, only less than half of pertussis-positive infants experienced the classic symptoms of pertussis.

    Zafer Kurugol Sr., Professor1, Sule Gokce, pediatrist1, Sohret Aydemir, Professor2, Asli Aslan, pediatrist1 and Guldane Koturoglu, professor1, (1)Pediatrics, Ege University, Izmir, Turkey, (2)Microbiology, Ege University, Izmir, Turkey

    Disclosures:

    Z. Kurugol Sr., None

    S. Gokce, None

    S. Aydemir, None

    A. Aslan, None

    G. Koturoglu, None

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