Methods: This study was performed on 172 infants ≤ 6 months of age, who were hospitalized for acute bronchiolitis in Ege University Hospital. Bordatella pertussis was studied by a real-time polymerase chain reaction in nasopharyngeal aspirates. Viral etiology (adenovirus, rhinovirus, respiratory syncytial virus, parainfluenza virus, human bocavirus, influenza virus, human metapnomovirus and coronovirus) was also determined by PCR. Cases were divided into 2 groups according to BP-positive or BP-negative. Clinical parameters, clinical severity scores and laboratory characteristics were compared between the BP-positive or BP-negative cases.
Results: A total of 172 infants were included in the study, 59.3 % were males. Overall, at least one pathogen was detected in 136/172 (81.4%) infants, of which RSV was the most prevalent detected in 89/172 (51.7%) infants. Bordetella pertussis involvement was found in 44 (25.6%) of the 172 infants hospitalized for viral bronchiolitis and 17 (9.8%) had only BP, as a sole pathogen. Of the 44 pertussis-positive infants, only 17 (38.6%) experienced a paroxysmal cough, 13 (29.5%) had whooping and 15 (34.1%) had post-tussive vomiting. There were no significant differences in the frequency of paroxysmal cough, whooping and post-tussive vomiting between the pertussis-positive and pertussis-negative infants. Clinical severity scores of pertussis-positive infants was similar with those of pertussis-negative infants (4.6 ± 1.8, 5.2 ± 2.5, respectively, p=0.123).
Conclusion: Bordetella pertussis infection is common in young infants hospitalized for acute bronchiolitis mostly as a coinfection. The clinical features of pertussis in the infants are not characteristic, only less than half of pertussis-positive infants experienced the classic symptoms of pertussis.
Z. Kurugol Sr.,
S. Aydemir, None
A. Aslan, None
G. Koturoglu, None
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