706. Proportions and Odds Ratio Analyses of Maternal and Perinatal Factors Associated with Neonatal Sepsis in a Developing Country
Session: Poster Abstract Session: They've Been Here a Billion Years! Pediatric Bacterial and Viral Infections
Thursday, October 27, 2016
Room: Poster Hall
Posters
  • Proportions and odds ratio analyses of Maternal and Perinatal Factors associated with Neonatal Sepsis ID week.pdf (195.5 kB)
  • Background: Determination of perinatal risk factors of neonatal sepsis will strengthen prevention, early diagnosis and treatment especially in a developing country context. The aim of this study was to determine the predominant maternal and perinatal factors associated with neonatal sepsis.

    Methods: This was a cross-sectional study conducted in a tertiary care hospital in Jos, Nigeria. Perinatal, maternal and demographic data were collected from mothers or care givers of 218 neonates suspected of sepsis using the World Health Organization young infant study group criteria. Neonatal sepsis was confirmed by positive cultures from blood cultures and/or Cerebrospinal fluid samples processed by standard methods in the microbiology laboratory. Data obtained were analyzed using Epi info version 3.5.3.

    Results: Of the 218 neonates (109 males, 99 females), 75 (34.4%) had culture positive sepsis and 99 (45.5%) had a birth weight of less than 2.5Kg. There was a higher rate of culture positive sepsis in low birth weight neonates (weight < 2.5 Kg, 46.5% culture positive) compared to weight ≥ 2.5 Kg (23.1 % culture positive). Fifteen (24.6%) of the mothers who had prolonged rupture of membranes (PROM > 24 hours), 15 (45.5%) of those with prolonged labor (> 14 hours), 11 (47.8%) of those with pre-eclampsia or eclampsia and 5 (71.4%) of those with Diabetes Mellitus (DM) had neonates with positive cultures. Maternal DM, birth weight, gestational age, prolonged labor, mode of delivery and history of pre-eclampsia or eclampsia were associated with neonatal sepsis with odds ratios greater than 1 while only maternal DM had a P value < 0.05.

    EGA = Expected Gestational Age, PROM = Prolonged rupture of membranes,

    DM = Diabetes Mellitus, UTI = Urinary Tract Infections

     

    Figure 1             Proportions of neonates with culture positive sepsis in relation to maternal and perinatal factors studied in Jos, Nigeria

     

    Conclusion: Based on proportions and odds ratio analyses, identified maternal and perinatal factors directly correlated to the presence of neonatal sepsis in a large proportion of the neonates studied. Antenatal and peripartum care addressing these factors will go a long way in reducing the incidence of neonatal sepsis and the morbidity and mortality attributed to it in developing countries.

     

    Kenneth Onyedibe, MBBS, MSc., PGD Infectious Diseases, FWACP, FMCPath., Medical Microbiology, Jos University Teaching Hospital,, Jos, Nigeria and Bose Toma, MBBS, FMCPead, Pediatrics, Jos University Teaching Hospital,, Jos, Nigeria

    Disclosures:

    K. Onyedibe, None

    B. Toma, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.