Methods: A PD analysis was conducted using data from a prospective pharmacokinetic study of cefazolin during cardiac surgery with cardiopulmonary bypass. Cefazolin prophylaxis was administered as per standard practice. Blood samples were collected after the preoperative dose, prior to intraoperative doses and within 15 minutes of wound closure. Cefazolin plasma concentrations were measured using liquid chromatography with tandem mass spectrometric detection. Patient and surgery data were collected from medical records, and SSIs were monitored for 30 days after surgery. Univariate analysis was used to identify potential risk factors for SSI (eg, age, body weight, cefazolin prophylaxis, duration of surgery) and multivariate analysis was performed with significant variables (p<0.1) using a backward, stepwise approach in a binary logistic-regression model (SYSTAT®).
Results: Forty patients (65 ±
Conclusion: This study demonstrates the potential importance of cefazolin concentration at wound closure (concclos) in providing optimal AP and preventing postoperative infections in patients undergoing cardiac surgery.
R. Ariano, None
R. Arora, None
H. Grocott, None