582. Prevalence of Enteric Opportunistic Parasites in Immunocompromised Cancer Patients
Session: Poster Abstract Session: Oh One World: Infections from Near and Far
Thursday, October 27, 2016
Room: Poster Hall
Posters
  • ID poster (1).pdf (596.7 kB)
  • Background: Parasitic infections are public health dilemma especially in developing countries. Immune system plays integral role in controlling & clearing these infections. Some chemotherapeutic agents used in cancer treatment damage body's anatomical barriers, damage rapidly dividing cells as blood cells or suppress bone marrow. Treatment with radiation, even if administered to limited target volume, causes immune dysfunction due to decrease in T & B lymphocytes. For these reasons infections were documented as one of most significant complications of therapy & major cause of mortality among cancer patients.This study was performed to estimate prevalence of enteric oppourtunistic parasites in Egyptian cancer patients.

    Methods: 200 patients were included & divided into 4 groups. Group A: 50 patients with haematological malignancies treated with chemotherapy. Group B : 50 patients with solid tumors treated with chemotherapy. Group C : 50 patients with solid tumors treated with radiation. Group D (control group): 50 patients free of malignancy but having GIT complaints. Different techniques were used to detect parasites including direct smear, ethyl-acetate concentration, staining with modified Ziehl Nelson & modified Trichrome stains, culture on Jone's media & culture on Nutrient Agar & Harrada Mori.

    Results: Oppourunistic parasites were more prevalent in cancer patients (57%) than in control group (43%) maybe due to reduction in local and cell-mediated responses in immunosuppressed patients that may favor establishment of some organisms. Blastocystis hominis was most prevalent protozoon in neoplastic patients (28.5%) followed by Cryptosporidium spp (23.5%), Microsporidium spp (9.5%), Cyclospora cayetanensis (2.5%) while least opportunistic parasite detected was Isospora belli (0.5%). Strongolyides stercolaris wasn't detected in any sample. Patients treated with radiation had higher rates of infection (68%) than those treated with chemotherapy (52%). Patients having solid organ tumors had significantly higher rates of infection (63%) than those with haematological malignancies (46%).

    Conclusion: This study highlights importance of routine screening for enteric opportunistic parasites in cancer and immune suppressed patients as this may be a treatable cause of some of patients' symptoms.

    Rita Wassef, MSc, Medical Parasitology and Immunology, National Hepatology and Tropical Medicine Research Institute, cairo, Egypt, Enas Rizk, MD, Medical Parasitology, Faculty of medicine- Cairo university, Cairo, Egypt and Raafat Abdel-Malek, MD, FRCR, Clinical Oncology, Cairo University, Cairo, Egypt

    Disclosures:

    R. Wassef, None

    E. Rizk, None

    R. Abdel-Malek, None

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