1529. Gastroesophageal Reflux Disease in HIV-infected Adults: Prevalence and Risk Factors of Moderate-Severe or Frequent Symptoms.
Session: Poster Abstract Session: HIV: Clinical Care
Friday, October 28, 2016
Room: Poster Hall

Gastroesophageal reflux disease (GERD) is common in the general population but its burden is unknown in HIV-infected adults. The aim of the study is to determine the prevalence of GERD and the clinical characteristics and risk factors associated with moderate-severe or frequent GERD symptoms among HIV-infected adults.


We conducted a cross-sectional study of 120 HIV-infected adults from two HIV clinics in Canada. The patients completed a validated GERD questionnaire during their clinic visits. GERD was defined as the presence of heartburn, acid regurgitation, or both. We considered two categories: symptoms occurring once a week or more as frequent, and those that cannot be ignored and affect the patient’s life as moderate-severe. A multivariate logistic regression analysis was used to assess risk factors associated with frequent or moderate-severe GERD symptoms.

Results: Eighty five HIV-infected adults were included in the analysis. Mean age was 44 years and median Body mass index (BMI) was 25. Of the sixty eight (81%) adults with GERD, 36 (52.9%) were classified as frequent and 42 (61.8%) moderate-severe. Sixty five(95.6%) patients who had GERD symptoms were taking medication to treat it. The majority of patients (92.3%) were on histamine 2 receptor antagonistsTwenty two patients had metabolic syndrome, of whom 19 (86.4%) had GERD symptoms. From the multivariate analysis, taking medications for GERD was the only variable associated with moderate to severe or frequent GERD symptoms {OR=14.7; 95% CI: (3.4- 62.9), P=0.04}. BMI and metabolic syndrome were not associated with GERD or its severity and frequency.

Conclusion: GERD is prevalent among HIV-infected adults, and over half of patients present with symptoms described as frequent and/or moderate-severe in intensity. Screening and management of GERD are important considerations as part of routine HIV care.

Mazen Bader, md, Medicine, hamilton health sciences, hamilton, ON, Canada and Yanqing Yi, phd, Memorial University of Newfoundland, St. John's, NF, Canada


M. Bader, None

Y. Yi, None

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