1205. Impact of food consumption on Helicobacter pylori eradication therapy: a Japanese community-based observational study.
Session: Poster Abstract Session: Clinical Infectious Diseases: Enteric Infections
Friday, October 28, 2016
Room: Poster Hall
Posters
  • IDweek2016 Poster No. 1205.pdf (693.7 kB)
  • Background: Helicobacter pylori (H. pylori) infection is a known risk of gastric cancer and success rate of eradication therapy is declining. Assessment of potential factors such as foods and nutrients that may affect H. pylori eradication therapy is important. To investigate the influence of foods and nutrients intake on H. pylori eradication therapy, we conducted a community-based and observational cohort study.

    Methods: In this community-based study, we screened 4014 Japanese men and women aged 30-79 years who participated in Kyushu and Okinawa Population Study using serum antibody to H. pylori (anti-H. pylori) and 13C-urea breath test (UBT). Of 4014, we followed 352 positive for both anti-H. pylori and UBT and who received triple drug therapy to eradicate H. pylori. Result of H. pylori eradication therapy was confirmed by UBT 8 weeks after completing therapy. We assessed participants’ demographic, characteristics; serum lipids, insulin, HbA1c and creatinine; and their food consumption and estimated nutrients intakes based on a short food frequency questionnaire (FFQ).

    Results: The success rate of triple drug therapy was 60.2% (212 of 352). The success group was significantly younger than the failure group, however there was no significant difference in male-to-female ratio, prevalence of smoking and drinking, and serum parameters between those two groups. Estimated intake amounts of iron, vitamin D, polyunsaturated fatty acids, n3-polyunsaturated fatty acids, n3-highlyunsaturated fatty acids (n3-HUFAs), and cholesterol were significantly lower in success group than in failure group. Backward elimination procedures selected dietary cholesterol and n3-HUFAs intakes and eggs and fish consumptions as factors having significant negative associations with eradication of H. pylori.

    Conclusion: Our results suggest that higher cholesterol and n3-HUFAs intakes and more frequent eggs and fish consumption may have a negative impact on triple drug therapy for H. pylori

    Hiroaki Ikezaki, MD, PhD1,2,3, Norihiro Furusyo, MD., PhD.4, Paul Jacques, DSc1, Masayuki Murata, Ph.D.4, Ernst Schaefer, MD2, Yoshihisa Urita, MD, PhD5 and Jun Hayashi, MD., PhD.6, (1)Nutritional Epidemiology Program, Jean Mayor USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, (2)Cardiovascular Nutrition Laboratory, Jean Mayor USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, (3)General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan, (4)Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan, (5)General Medicine and Emergency Care, Toho University School of Medicine Omori Hospital, Tokyo, Japan, (6)Kyushu General Internal Medicine Center, Hara-Doi Hospital, Fukuoka, Japan

    Disclosures:

    H. Ikezaki, None

    N. Furusyo, None

    P. Jacques, None

    M. Murata, None

    E. Schaefer, None

    Y. Urita, None

    J. Hayashi, None

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