Methods: In this community-based study, we screened 4014 Japanese men and women aged 30-79 years who participated in Kyushu and Okinawa Population Study using serum antibody to H. pylori (anti-H. pylori) and 13C-urea breath test (UBT). Of 4014, we followed 352 positive for both anti-H. pylori and UBT and who received triple drug therapy to eradicate H. pylori. Result of H. pylori eradication therapy was confirmed by UBT 8 weeks after completing therapy. We assessed participants’ demographic, characteristics; serum lipids, insulin, HbA1c and creatinine; and their food consumption and estimated nutrients intakes based on a short food frequency questionnaire (FFQ).
Results: The success rate of triple drug therapy was 60.2% (212 of 352). The success group was significantly younger than the failure group, however there was no significant difference in male-to-female ratio, prevalence of smoking and drinking, and serum parameters between those two groups. Estimated intake amounts of iron, vitamin D, polyunsaturated fatty acids, n3-polyunsaturated fatty acids, n3-highlyunsaturated fatty acids (n3-HUFAs), and cholesterol were significantly lower in success group than in failure group. Backward elimination procedures selected dietary cholesterol and n3-HUFAs intakes and eggs and fish consumptions as factors having significant negative associations with eradication of H. pylori.
Conclusion: Our results suggest that higher cholesterol and n3-HUFAs intakes and more frequent eggs and fish consumption may have a negative impact on triple drug therapy for H. pylori.
P. Jacques, None
M. Murata, None
E. Schaefer, None
Y. Urita, None
J. Hayashi, None