1501. HIV Transmitted Drug Resistant in Rural Southern Community
Session: Poster Abstract Session: HIV Drug Resistance
Friday, October 28, 2016
Room: Poster Hall
Background:

Transmitted drug resistance (TDR) is a major public health concern in patients with HIV. This study is first retrospective study to assess the prevalence, epidemiology, risk factor for (TDR) and evaluate a possible contribution of transmission clusters to the spread of resistant virus in newly diagnosed, treatment naïve HIV-Infected Patients in Rural Eastern NC

Methods:

We conducted a retrospective chart review of all newly diagnosed HIV patients who have not been on antiretroviral therapy and are seen for the first time at (BSOMHIVP). We collected demographic information including age, sex, county of residence and HIV risk factor, laboratory information including CD4 count, HIV viral load and HIV genotype at first visit. We recorded the presence or absence of TDR as well as individual mutations in the (PI), NRTI,NNRTI and INI. Only major mutations as defined by Stanford HIV Drug Resistance Database were included in the analysis. Associations between categorical variables were investigated using Fisher’s exact test. Logistic regression was used to identify possible predictors of TDR. A significance level of 0.05 was adopted for all statistical tests. All analyses were conducted in SAS 9.4 (SAS Institute Inc., Cary, NC).

Results: We reviewed the charts of 210 patients: forty five patients were excluded due to variable reasons including unavailable genotype results, or very low viral load. The prevalence of TDR was 20% overall, with 18 % resistance to NNRTIs, 1 % to NRTIs, 0.6% to PIs and 0% to the INI. Out of those with NNRTI associated TDR, the most frequently observed TDR mutations detected was K103N 59%. . Gender, Race and county of residence were not associated with presence of TDR but age <25 and men who have sex with men (MSM) sexual preference were independent risk factors for TDR (p value of 0.0058 and 0.0338 respectively)

Conclusion: TDR) was detected in 20 % of treatment-naıve patients, with resistance to NNRTIs being the most common. Age below 25 year-old and being MSM were the most common predicative risk factor of acquiring resistant HIV. Targeted infection prevention programs are needed in order to limit the further spread of resistant HIV-1 in this population in Eastern North Carolina.

Ahmed Abubaker, MD, Infectious Diseases, East Carolina University/ Vidant Medical Center, Greenville, NC, Nada Fadul, MD, Internal Medicine, East Carolina University, Greenville, NC, Xiangming Fang, PhD, East Carolina University, Greenville, NC and Salma Mohamed, MD, Kassala University, Kassala, Sudan

Disclosures:

A. Abubaker, None

N. Fadul, None

X. Fang, None

S. Mohamed, None

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