Methods: Twenty eight male Wistar rats in weights ranging from 200 to 250 g, were used in this study. Rats were divided into 4 groups randomly. In all groups, bacterial peritonitis was created by cecal ligation and puncture method. Group 1 was considered as sham group. Groups 2, 3, and 4 were given, respectively, saline, a single dose of ertapenem and a dose of ertapenem intraperitoneally every day. Intra-abdominal adhesions were assessed 7 days after surgery by histopathological examination. Microbiological examination was performed through the ascites obtained.
Results: Adhesion score decreased significantly by the application of ertapenem (p <0.001) and fibrosis scores were found to be significantly lower (p:0.005). Among all groups, the relationship between the decrease in the number of colonies and antibiotics application was not statistically significant (p:0.109). No statistically significant difference was found between the group given single dose of ertapenem and the group given multiple ertapenem (p:1).
Conclusion: In the light of the data provided, peritoneal lavage with ertapenem appears to be effective in preventing the adhesion in septic rat abdomen. As no difference was detected at the end of a single dose and multiple dose administration of antibiotics in the adhesion scores, a single dose after surgery seems to be enough. It is thought that, the results need to be interpreted with a clinical study.
O. Yılmaz, None
M. Yıldırım, None
I. Akbulut, None
S. Serin Senger, None
G. Akkoclu, None
G. Diniz Unlu, None