
Antimicrobials (MIC50/90; mg/L) | |||||||
Pathogen | n | ICL | VAN | LIN | DAP | TMP | TMP/SMX |
S.aureus | 1,178 | 0.06/0.12 | 1/1 | 1/1 | 0.25/0.5 | 1/2 | 0.06/0.12 |
MRSA | 582 | 0.06/0.12 | 1/1 | 1/1 | 0.25/0.5 | 1/8 | 0.06/0.25 |
MSSA | 596 | 0.06/0.12 | 1/1 | 1/1 | 0.25/0.5 | 1/2 | 0.06/0.06 |
Beta-hemolytic streptococci | 199 | 0.06/0.25 | 0.25/0.5 | 1/1 | 0.12/0.25 | 1/2 | 0.12/0.25 |
S. pneumoniae | 259 | 0.06/0.2 | 0.25/0.5 | 1/1 | 0.12/0.25 | 2/64 | 0.25/8 |
Total | 1636 |
Globally, ICL MIC50/90s for S. aureus including MRSA were l6-fold lower than those for TMP and similar to TMP/SMX. ICL MIC 50/90s for beta-hemolytic streptococci were 8-fold lower than for TMP and 2-fold lower than for TMP/SMX. ICL 50/90 were 32-fold lower than TMP and 4-fold lower than TMP/SMX for S. pneumoniae. ICL MIC 50/90 were 0.06/0.12, 0.06/0.25, and 0.06/2 for US S. aureus, beta-hemolytic Streptococcus, and S. pneumoniae, respectively; corresponding values for European isolates were 0.6/0.12, 0.12/0.25, and 0.6/4, respectively.
Conclusion: ICL was potently active against all S. aureus, beta-hemolytic streptococcus, and S. pneumoniae clinical SSSI and HABP isolates globally from 2012-2014. ICL could be an important new therapeutic option for the treatment of SSSI and HABP, especially cases caused by multidrug resistant Gram-positive bacteria. Pivotal clinical trials are warranted to evaluate ICL for the indications of SSSI and HABP.

D. Huang,
Motif BioSciences:
Employee
,
Salary
M. Wilcox, MERCK: Grant Investigator , Scientific Advisor and Speaker's Bureau , Consulting fee , Research support and Speaker honorarium
PFIZER: Grant Investigator , Scientific Advisor and Speaker's Bureau , Consulting fee , Research support and Speaker honorarium
SUMMIT: Grant Investigator and Scientific Advisor , Consulting fee and Research support
SERES: Grant Investigator , Scientific Advisor and Speaker's Bureau , Consulting fee , Research support and Speaker honorarium
DA VOLTERRA: Grant Investigator and Scientific Advisor , Consulting fee and Research support
BIOMERIEUX: Investigator and Scientific Advisor , Consulting fee and Research support
ALERE: Grant Investigator , Scientific Advisor and Speaker's Bureau , Consulting fee , Research support and Speaker honorarium
ACTELION: Grant Investigator and Scientific Advisor , Consulting fee and Research support
M. Dryden, Motif BioSciences: Scientific Advisor , Consulting fee
G. Corey, None
R. Shukla, Motif BioSciences: Employee , Salary