1326. Outcomes Associated with Outpatient Antimicrobial Therapy Program
Session: Poster Abstract Session: Clinical Practice Issues
Friday, October 28, 2016
Room: Poster Hall
  • ID Week Poster_Stacy, Beth.pdf (493.0 kB)
  • Background: Outpatient Antimicrobial Therapy (OPAT) has been shown to have similar clinical outcomes to therapy completed in the inpatient setting with an overall clinical success rate above 85%. Approximately 10 to 25% of patients discharged with OPAT are readmitted and approximately 70% of those readmissions are directly related to OPAT. The primary purpose of this study is to identify risk factors associated with therapy-related readmissions in OPAT patients who discharged from an academic medical center.

    Methods: This retrospective single center study evaluated 184 adults diagnosed with an infectious process and subsequently discharged with intravenous antimicrobials for a treatment duration of at least 7 days. Patients readmitted within 90 days of discharge were compared to patients without readmission. Multivariate logistic regression was completed to identify factors associated with readmission.

    Results: Patients were treated with OPAT for a median of 42 days in both groups. The majority of infections in both groups were culture-positive, with multi-drug resistant organisms isolated in 44.2% of the readmitted group and 42.6% of the not-readmitted group. The overall readmission rate for OPAT patients was 33%. The most common reason for readmission was worsening of infection (56% of all readmissions), with adverse events related to OPAT (8%) and acute kidney injury (8%) also being common reasons for readmission. When controlling for confounding variables, patients were more likely to be readmitted if being treated for bloodstream infection or if they had a history of readmission in the previous 12 months.

    Conclusion: Readmission rate related to OPAT at this academic medical center was higher than reported in previous literature. Patients with history of readmission may be at higher risk for readmission related to OPAT which could potentially be related to complexity of comorbidities. Patients with a history of readmission or bloodstream infection may require more intense monitoring and follow up.

    Elizabeth Stacy, Pharm.D., Siyun Liao, Pharm.D., PhD, BCPS, Kristen Carter, Pharm.D., BCPS, Jennifer Forrester, MD and Maria Guido, Pharm.D., BCPS, UC Health - University of Cincinnati Medical Center, Cincinnati, OH


    E. Stacy, None

    S. Liao, None

    K. Carter, None

    J. Forrester, None

    M. Guido, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.