Background: In Colombia there has not been published any study that characterizes the general population of patients with infections of the central nervous system (CNS). The purpose of this study is to describe the autopsy findings with CNS infections at the Hospital Universitario de Santander (HUS).
Methods: Descriptive retrospective study, adjusted to the current national and international regulations on human research. We reviewed the autopsy protocols performed at the Department of Pathology of the Universidad Industrial de Santander (UIS) between 2004-2015 and selected those with CNS infection as a final diagnosis, of these there were evaluated the pathological findings and demographic variables.
Results: Among 3117 autopsy protocols reviewed, there were found 200 cases of CNS infection, 130 men (65%) and 70 women (35%), with average age of 26.5 years. 113 cases were caused by opportunistic agents: C. neoformans (38 cases - 33.62%), Toxoplasma gondii, and M. tuberculosis with 32 cases (28.31%) each. In 72 cases (63,71%) HIV co-infection was found. Of the 87 cases not associated with opportunistic agents, 59 (67.81%) were caused by pyogenic microorganisms, followed by viral agents in 25 cases (28.73 %).
Conclusion: The high mortality reported in CNS infections, especially at the extremes of life is directly influenced by the poor correlation between clinical and post-mortem diagnosis, which difficults the approach of the disease and promotes the development of complications, because of this results necessary conducting similar studies for the characterization of these entities, which may contribute to the clinical suspicion of specific infectious agents.
J. C. Mantilla Hernández,
K. A. Jerez Torra, None