Methods: Fifty-one patients referred to our ID clinic for HCV evaluation from various referral sources including psychiatry were identified. The treatment group consisted of 20 patients receiving OST with suboxone (55%), methadone (35%), or subutex (10%). 31 matched controls not on OST with similar demographics were identified for comparison. Chi-square testing was performed to determine differences in HCV cure between the two groups. Adverse events and rate of compliance with medical visits was assessed.
Results: The majority of the fifty-one patients referred to our ID clinic for HCV evaluation were treated with SOF-based regimens. Patient demographics are described in Table 1. All patients on OST completed HCV treatment. Of patients on OST who have completed follow up, the interim SVR12 is 100%. In matched controls that were not on OST, the SVR12 is 100%. Treatment was well tolerated in both groups.
Conclusion: SOF-based regimens provided high rates of SVR in patients on OST. Patients can safely be treated in the setting of OST and mental illness however may require a patient navigator to complete follow up. Linkage of these patients can be established by collaborative networks among methadone clinics, psychiatrists, and HCV specialists. Addressing drug addiction in rural America is vital to reducing the spread of hepatitis C.
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