2131. HIV Infected Persons Are at High Risk of Developing Precancerous Lesion of the Oral Cavity
Session: Poster Abstract Session: HIV: Cancers, HPV, Dysplasia
Saturday, October 29, 2016
Room: Poster Hall
Background: Most oral cancers first manifest as a visible mucosal precancerous lesion. Early diagnosis and treatment of the lesion is desirable. Particularly for HIV positive patient, early diagnosis is important because treatment becomes more difficult than general patients. We have evaluated the risk of developing precancerous lesion of the oral cavity in HIV infected persons in Japan by a case control study.

Methods: We have performed oral cancer screening in HIV infected persons. The screenings was performed on 82 HIV patients who visited out-patient clinic of our hospital from March 2013 to March 2015. The protocol is same to this in Oral Cancer Screening Project in Kanagawa prefecture (OCSPK). The patients filled-up the questionnaire form about family history, past history, tabacco, and alcohol use, then subjected to examination of oral cavity by direct inspection. Biopsy was performed on abnormal lesion. The content of data was extracted from these screenings, analyzed and compared with data from OCSPK.

Results: Ten patients were female sex, others were male, and the average age was 52.7 years old. Thirty-three patients (40.2%) had a smoking habit. Twelve patients (14.6%) had an alcohol habit. Twenty-four (29.3%) patients have a family cancer history within second-degree relative. Although there was no patient complicated with oral cancer, abnormality in oral mucosa was pointed out in 13 cases. Thirteen cases were subjected to pathological examination and 12 cases (14.6%) were diagnosed as having precancerous lesion. Thirty-five cases (3.7%) were diagnosed as having precancerous lesion in OCSPK, in which 935 HIV non-infected patients participated. Smoking habit, alcohol habit and family cancer history were reported in 5.6%, 12.0%, and 46.1% patients in OCSPK, respectively. The risk of developing precancerous lesion was higher in HIV patients than in OCSPK controls (OR 3.988; 95% CI 1.385-11.489; p = .010). People who smoke are more likely to develop a precancerous lesion than non-smoker (OR 3.305; 95% CI 1.144-9.544; p = .027).

Conclusion: Although oral precancerous lesion was frequently seen in HIV patient, the relative risk is almost same to smoking. Therefore HIV patients should be encouraged oral cancer screening and cessation of smoking.

Hiroshi Chikumaru, DMD, PhD1, Makiko Okubo, DMD1, Atsuhisa Ueda, MD, MPH2, Akira Shirai, MD, PhD2, Yoshimi Ishikawa, DMD, PhD3, Kenji Mitsudo, MDM, PhD1, Yoshihide Ohta, DMD, PhD4, Akihiro Kaneko, DMD, PhD4, Iwai Tohnai, DMD, PhD1 and Yoshiaki Ishigatsubo, MD, PhD2, (1)Department of Oral & Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan, (2)Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, (3)Department of Oral Surgery, Fujisawa City Hospital, Fujisawa, Japan, (4)Department of Oral Surgery, Tokai University Hospital, Isehara, Japan

Disclosures:

H. Chikumaru, None

M. Okubo, None

A. Ueda, None

A. Shirai, None

Y. Ishikawa, None

K. Mitsudo, None

Y. Ohta, None

A. Kaneko, None

I. Tohnai, None

Y. Ishigatsubo, None

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