981. Patients with Advanced Stage Pressure Ulcers: Identifying an Opportunity for Targeted Antimicrobial Stewardship
Session: Poster Abstract Session: Antibiotic Stewardship: General Acute Care Implementation and Outcomes
Friday, October 28, 2016
Room: Poster Hall
  • MGPosterDraft5.pdf (371.8 kB)
  • Background:In the setting of a larger study to describe process and outcomes for patients with advanced pressure ulcers (APU) present on hospital admission, we sought to characterize antimicrobial utilization and infectious complications among this patient cohort. This data may inform the development of focused antimicrobial stewardship activities (ASP).

    Methods:A retrospective cohort study was conducted of all adult patients hospitalized in 2014 at Montefiore Health System (1 rehabilitation and 4 acute care facilities with > 1400 licensed beds) with advance stage pressure ulcers (APU) (Stage III, IV, Unstageable and Suspected Deep Tissue Injury) on the trunk (back, buttocks, hips). Demographic, exposures, process and outcomes measures were extracted from internal clinical and administrative databases for all eligible patients.

    Results: A total of 1,501 patients with APU were identified. Patients were older (median: 76 years; IQR: 64-86 years), and 56.83% were female. Patients had high comorbidity levels with a median combined Charlson Comorbidity Index Score of 7.00 and an IQR of 4.00. The most common primary admission diagnoses were altered mental status, fever or septicemia. Almost 90% of APU patients received antibiotics. Most received several antibiotic courses (median 5, range 1-83 courses) within 2014 of which the most commonly prescribed inpatient antibiotics were: vancomycin (24%), ceftriaxone (20%), piperacillin/tazobactam (19%), ciprofloxacin (6%) and cefepime (4%). Infectious complications were common: 199 patients (14%) had bacteremia, where there were 60 patients (4%) with multidrug resistant pathogens, and 10.9% (163/1,501) had C. difficile.Although many APU patients received infectious diseases (31%) or wound care (30.4%) consultation the indication for antibiotics was difficult to determine (i.e, for wound vs. other source). The cohort had an in-house mortality rate of 10.3% and a 30-day readmission rate of 20.3%.

    Conclusion: This descriptive data suggest that APU patients consume extensive antimicrobials and have a high burden of adverse infectious complications. This population may therefore benefit from targeted ASP activities. Challenges may exist in crafting interventions for such a complex population.

    Marné Garretson, MPH1, Anna Flattau, MD, MSc, MS1, Maryrose Defino, RN, MS, CPHQ1, Arinola Makinde, RN1, Elizabeth Gancher, MD1, Cary Andrews, PA, MS, CWS1 and Belinda Ostrowsky, MD, MPH, FIDSA, FSHEA2, (1)Montefiore Medical Center, Bronx, NY, (2)Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Bronx, NY


    M. Garretson, None

    A. Flattau, None

    M. Defino, None

    A. Makinde, None

    E. Gancher, None

    C. Andrews, None

    B. Ostrowsky, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.