596. Severe Adult Dengue Cases admitted to the Intensive Care Unit in 2015- A Single-Centre Experience, Singapore
Session: Poster Abstract Session: Oh One World: Infections from Near and Far
Thursday, October 27, 2016
Room: Poster Hall
  • IIDE Poster DengueOct_upload.pdf (664.4 kB)
  • Background:

    Singapore anticipates a record high number of dengue cases in 2016. Severe dengue due to plasma leakage, dengue hemorrhagic fever is well recognised. Advanced age and certain comorbidities may also contribute to severe presentation.


    Retrospective case series/audit of all confirmed dengue cases (Dengue NS1 positive, compatible clinical presentation) admitted to our institution’s ICU in 2015. The goal is to identify areas to improve management and processes.


    14 adult cases were reviewed, 93% had primary dengue. Dengue serotype was identified in 13 patients (5 serotype 1, 8 serotype 2). 8 patients were women. The median age was 52 years (range 21-79). One patient had travelled from India in the preceding two weeks. 9/14 had Charlson score of ≤ 1.

    12/14 were admitted to ICU due to shock, and 8 required inotropes/vasopressors (7 received dopamine, 3 noradrenaline, 2 vasopressin). 10/14 were admitted at day 1-3 of fever. Median duration of ICU admission was 3 days (range 2-7). Cardiac involvement was seen in 6 patients (dynamic ECG changes, and/or Troponin increase) with median age 42.5 years (range 21-79). 4/6 patients had echocardiography done, and 3 had depressed systolic function. Thrombocytopenia appeared more severe in those with cardiac involvement compared with those without (mean minimum platelet count 27 vs 74.6 x 109/L). Evidence of plasma leakage was seen in 5 patients (3 patients also had cardiac involvement). Gastrointestinal bleeding occurred in 2 patients. Two patients died.


    Important observations from this case series includes shock early in dengue course requiring inotropes. Although plasma leakage was observed for a proportion of cases, a number of patients (including younger patients) had signs of cardiac involvement. Cardiac involvement in dengue has been reported (transient depressed myocardial function, electrical abnormalities).

    Shock in early dengue may need to be viewed and managed differently. This will need a multi-disciplinary approach, with appropriate assessment and monitoring (non-invasive methods, echocardiography, cardiac enzymes), judicious and tailored use of fluids and inotropes. Case-control studies are needed to evaluate these observations and trial various approaches. 

    Sapna Sadarangani, MBBS1, Monica Chan, MBBS1, Tau Hong Lee, MBBS1, Li Min Ling, MBBS1, Win Mar Kyaw, MBBS2, Angela Chow, MBBS, PhD2, Sennen Lew, MBBS3 and Yee Sin Leo, MPH, FAMS, FRCP4, (1)Infectious Diseases, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore, (2)Clinical Epidemiology, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore, (3)Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore, (4)Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore


    S. Sadarangani, None

    M. Chan, None

    T. H. Lee, None

    L. M. Ling, None

    W. Mar Kyaw, None

    A. Chow, None

    S. Lew, None

    Y. S. Leo, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.