Methods: VZV was isolated from vesicular lesions of the pediatric patients hospitalized for varicella or herpes zoster at Seoul National University Children’s Hospital, 2009-2015. To distinguish the vaccine-type strain from the wild-type strain, sequencing analysis of open reading frame (ORF) 62 was performed. The genotype was determined by sequencing analysis of ORF 22.
Results: Twenty-three patients with varicella and 28 patients with herpes zoster were included (median age 10.0 years, 16 days-19 years), and 44 patients (86.3%) had underlying diseases. Among 28 patients with herpes zoster, 12 patients had a past history of varicella and 1 patient had herpes zoster. According to the sequencing analysis of ORF 62, 2 vaccine-type strains were identified in children with herpes zoster without past history of varicella. One vaccine-type strain was identified from a child with retinoblastoma receiving chemotherapy after 22 months of varicella vaccination, and the other was from an immunocompetent child after 5 months of vaccination. Other VZV strains were wild-type strains. Genotypes by ORF 22 were determined genotype J in all patients except one. Genotype E was identified in an infant with varicella imported from Egypt.
B. O. Kwak,
C. E. Oh, None
H. S. Kim, None
E. H. Choi, None
H. J. Lee, None
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