1256. Acute Onset of Pneumococcal Pneumonia Following Hospitalization and Surgery
Session: Poster Abstract Session: Clinical Infectious Diseases: Respiratory Infections
Friday, October 28, 2016
Room: Poster Hall
Posters
  • Post-Instrumentation pneumonia PDF IDSA.pdf (239.6 kB)
  • Background: Pneumococcal pneumonia results when bacteria that colonize the respiratory tract are carried to the alveoli and replicate, causing an inflammatory response. We describe a group of patients who developed pneumococcal pneumonia immediately following intubation or respiratory tract instrumentation. We hypothesize that these interventions disrupt normal anatomic protective barriers, greatly increasing the risk of infection.

    Methods: We analyzed a database of 495 patients with documented pneumococcal pneumonia to identify those who developed this infection within 4 days of an invasive procedure involving the respiratory tract. None had symptoms of acute respiratory infection at the time of the procedure. Data including date/type of procedure, date of onset of pneumonia, culture and imaging results, treatment and mortality were extracted. Date of onset of pneumonia was recorded as the time that the patient first developed clinical signs of pneumonia including fever, leukocytosis, or new infiltrate on chest x-ray. When these clinical signs were obscured by a prior condition, physician suspicion was used as a surrogate indicator of the date of onset.

    Results: Of 495 patients with pneumococcal pneumonia, 26 developed pneumonia within 4 days of an invasive procedure -- 3 after bronchoscopy and 23 after intubation. The median time from the procedure to the onset of pneumonia was 1 day. Etiologic diagnosis was made by documenting Gram positive diplococci on Gram stain and isolation of S. pneumoniae from sputum or tracheal secretions; 1 patient had bacteremia. Twenty-five patients recovered and were discharged; 1 died in the hospital 20 days after diagnosis. Physicians often attributed clinical signs of infection to the condition that led to instrumentation rather than considering the possibility of a new pneumonia; when they did recognize pneumonia, their selection of broad-spectrum antibiotics suggested they did not consider pneumococcus as a possible cause.

    Conclusion: Instrumentation bypasses normal protective barriers and may carry organisms from the upper to the lower airways, leading to pneumonia. Pneumonia should be considered as a complication of airway instrumentation, and pneumococcus should be regarded as a possible cause.

    Julianna G. Gardner, BA1, Rahul S. Kamath, B.S.1, Adriana M. Rueda, MD2,3 and Daniel M. Musher, MD1,4, (1)Department of Medicine, Baylor College of Medicine, Houston, TX, (2)Section of Infectious Diseases, Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, (3)Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX, (4)Medical Care Line, Infectious Diseases, Michael E. DeBakey VA Medical Center, Houston, TX

    Disclosures:

    J. G. Gardner, None

    R. S. Kamath, None

    A. M. Rueda, None

    D. M. Musher, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.