2225. Evolving Composition of the Human Intestinal Microbiota Following Fecal Transplantation
Session: Poster Abstract Session: Microbiome: GI
Saturday, October 29, 2016
Room: Poster Hall
Posters
  • Evolving human intestinal microbiota composition following FMT - IDWeek 2016 (Poster 2225) - Final.pdf (333.7 kB)
  • Background: Fecal microbiota transplantation (FMT) for treatment of Clostridium difficile infection (CDI) is associated with success rates of >90% and has become the standard of care for treatment of CDI refractory to conventional antimicrobial therapy. Although the presumed mechanism of action is restoration of “healthy” intestinal microbial diversity, the time course and process of evolution from an unhealthy to healthy intestinal microbiota is not well understood.

    Methods: 48 patients were enrolled over an 18 month period. Stool samples were studied from patients prior to and every 90 days following stool transplantation for 12 months. Only four patients completed the entire 12 month post-FMT followup portion of the study.

    Results: Fecal bacterial operational taxonomic units (OTUs) and phylogenetic diversity (PD) were greater in the donor than patients at baseline, (ie, day 0 (p<0.05)). Patient OTUs and PD increased at each interval following FMT from day 0 to day 90, day 180 and day 360 (p<0.05). OTUs and PD were not different in DD vs. patients at 3 months, 6 months, or one year (p>0.05).

    Conclusion: Patients tended (p=0.07) to have more OTUs at 3 months compared to baseline. Microbiota diversity (as measured by OTU) continued to evolve over 6 and even 12 months for 3/4 patients. Based on our long term followup studies of patients following FMT, gut microbiota recovery following FMT is not instantaneous, but appears to be a process of evolution following FMT that occurs over ≥ 12 months.

    John Farrell, MD, Medicine & Microbiology, University of Illinois, Peoria, IL and Daniel Martin, MD, Medicine, University of Illinois College of Medicine, Peoria, IL

    Disclosures:

    J. Farrell, None

    D. Martin, None

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