423. Seroprevalence of Hepatitis E Virus infection and their asociated risk factors in pregnant women in Chennai,Tamil Nadu.
Session: Poster Abstract Session: Hepatitis A and Hepatitis E
Thursday, October 27, 2016
Room: Poster Hall
Posters
  • Slide1.JPG (2.3 MB)
  • Background:

    Hepatitis E virus (HEV) infection is a major public health problem in developing countries, presenting as acute self-limiting hepatitis. Approximately 20 million cases of HEV infection occurs every year globally. In endemic areas, it is the most common cause of fulminant hepatic failure. Infection in pregnant women is more common and fatal in the third trimester. Present study was undertaken with the objective of estimating the prevalence of HEV infection in pregnant women and their associated risk factors in Chennai, Tamil Nadu.

    Methods:

    This prospective study was conducted in the Department of Experimental Medicine, The Tamilnadu Dr.MGR Medical University, Chennai from October 2014 to December 2015. Risk factors for acquiring to HEV infection in consenting pregnant women was assessed through a semi structured questionnaire. Two ml of blood was collected and serum separated and stored at -200C until further testing. All the serum samples were screened for HEV IgG antibodies using DIA.PRO Enzyme Linked Immunosorbant Assay (ELISA) Kit-Italy. The results were analyzed using SPSS 16 software.

    Results:

    Among 180 pregnant women enrolled, age ranged from 18-40 years with mean 25 years (SD 3.9). Out of the total 14% (25/180) were positive for HEV IgG antibodies. Figure 1 shows age wise seropositivity. Majority of them (15/25) were in third trimester. Figure 2 shows seropositivity in each trimester. Logistic regression analysis showed women with no drinking water facilities, consumption of untreated water and non vegetarians are 2 times more likely to be seropositive (95% CI 1.5-3.75, 1.386-6.99, 1.5-6.33 respectively). Women who had contact with animals are 1.5 times likely to be infected (95% CI 1.2-4.3). Women living in overcrowded house and in houses with less rooms are 3 times more prone for acquiring infection (95% CI -2.10-4.26,1.7-6.55 respectively).

    Conclusion:

    In the present study,14% of women were positive for HEV IgG antibodies. Based on the associated risk factors, drinking water facility should be made available in households and public should be educated on water and food borne diseases and avoid overcrowding. All pregnant women should be screened for HEV infection by ELISA and follow up for clinical signs and symptoms of hepatitis.


     

    K Sivasangeetha, M.D.1, S Geethalakshmi, M.D., Ph.D2, G Thatchinamoorthy, MSc1, P Gouthami, B.Sc3 and S Mini Jacob, M.D1, (1)Department of Experimental Medicine, The Tamilnadu Dr MGR Medical University, Chennai, India, (2)The Tamilnadu Dr MGR Medical University, Chennai, India, (3)Department of Experimental Medicine, The Tamil Nadu Dr MGR Medical University, Chennai, India

    Disclosures:

    K. Sivasangeetha, None

    S. Geethalakshmi, None

    G. Thatchinamoorthy, None

    P. Gouthami, None

    S. Mini Jacob, None

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